Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review

The coronavirus disease 2019 pandemic is an ongoing concern for medical care worldwide. Since its emergence, multiple COVID-19 vaccines have been designed, allowing for more effective control of the pandemic. COVID-19 vaccines, like any other form of medical intervention, may cause adverse and unfor...

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Main Authors: Kacper Chrostowski, Michał Piasecki, Joanna Bielewicz
Format: Article
Language:English
Published: Termedia Publishing House 2023-02-01
Series:Central European Journal of Immunology
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Online Access:https://www.termedia.pl/Trigeminal-neuralgia-occurring-after-the-third-dose-of-Pfizer-BioNTech-COVID-19-vaccine-Complication-or-coincidence-r-nAn-illustrative-case-report-and-literature-review,10,50183,1,1.html
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author Kacper Chrostowski
Michał Piasecki
Joanna Bielewicz
author_facet Kacper Chrostowski
Michał Piasecki
Joanna Bielewicz
author_sort Kacper Chrostowski
collection DOAJ
description The coronavirus disease 2019 pandemic is an ongoing concern for medical care worldwide. Since its emergence, multiple COVID-19 vaccines have been designed, allowing for more effective control of the pandemic. COVID-19 vaccines, like any other form of medical intervention, may cause adverse and unforeseen side effects, varying in frequency and severity. Determining a correlation between the occurring symptoms and the vaccination is often a challenging task, requiring multiple data sources and reported cases. So far, there have been multiple reports of trigeminal neuralgia developing after COVID-19 vaccination. A 36-year-old woman was admitted to the Emergency Ward due to chronic pain attacks in the left side of her face. The pain appeared two months ago, on the day following the vaccination using the third dose of the Pfizer BioNTech COVID-19 vaccine. At the Neurology Department she was diagnosed with trigeminal neuralgia. Based on the lack of any obvious causes, relation to the vaccination, and other similar reports, we assumed that the trigeminal neuralgia was a complication of the vaccination. Hospital treatment consisted of oxcarbazepine, dexamethasone and pregabalin. Treatment was successful, with transient episodes of exacerbation. Six months after the onset of the disorder the patient remains without pain. We believe that the presented case supports the possibility of trigeminal neuralgia occurring in relation to the Pfizer BioNTech COVID-19 vaccine administration. Additional reports may further contribute to establishing a certain link.
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spelling doaj-art-12cd58a2e4f84651b7c4e3d191166ffd2025-08-20T02:09:38ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242023-02-01481758010.5114/ceji.2023.12530950183Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature reviewKacper ChrostowskiMichał PiaseckiJoanna BielewiczThe coronavirus disease 2019 pandemic is an ongoing concern for medical care worldwide. Since its emergence, multiple COVID-19 vaccines have been designed, allowing for more effective control of the pandemic. COVID-19 vaccines, like any other form of medical intervention, may cause adverse and unforeseen side effects, varying in frequency and severity. Determining a correlation between the occurring symptoms and the vaccination is often a challenging task, requiring multiple data sources and reported cases. So far, there have been multiple reports of trigeminal neuralgia developing after COVID-19 vaccination. A 36-year-old woman was admitted to the Emergency Ward due to chronic pain attacks in the left side of her face. The pain appeared two months ago, on the day following the vaccination using the third dose of the Pfizer BioNTech COVID-19 vaccine. At the Neurology Department she was diagnosed with trigeminal neuralgia. Based on the lack of any obvious causes, relation to the vaccination, and other similar reports, we assumed that the trigeminal neuralgia was a complication of the vaccination. Hospital treatment consisted of oxcarbazepine, dexamethasone and pregabalin. Treatment was successful, with transient episodes of exacerbation. Six months after the onset of the disorder the patient remains without pain. We believe that the presented case supports the possibility of trigeminal neuralgia occurring in relation to the Pfizer BioNTech COVID-19 vaccine administration. Additional reports may further contribute to establishing a certain link.https://www.termedia.pl/Trigeminal-neuralgia-occurring-after-the-third-dose-of-Pfizer-BioNTech-COVID-19-vaccine-Complication-or-coincidence-r-nAn-illustrative-case-report-and-literature-review,10,50183,1,1.htmladverse effects case report sars-cov-2 trigeminal neuralgia covid-19 vaccine
spellingShingle Kacper Chrostowski
Michał Piasecki
Joanna Bielewicz
Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review
Central European Journal of Immunology
adverse effects
case report
sars-cov-2
trigeminal neuralgia
covid-19 vaccine
title Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review
title_full Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review
title_fullStr Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review
title_full_unstemmed Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review
title_short Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review
title_sort trigeminal neuralgia occurring after the third dose of pfizer biontech covid 19 vaccine complication or coincidence an illustrative case report and literature review
topic adverse effects
case report
sars-cov-2
trigeminal neuralgia
covid-19 vaccine
url https://www.termedia.pl/Trigeminal-neuralgia-occurring-after-the-third-dose-of-Pfizer-BioNTech-COVID-19-vaccine-Complication-or-coincidence-r-nAn-illustrative-case-report-and-literature-review,10,50183,1,1.html
work_keys_str_mv AT kacperchrostowski trigeminalneuralgiaoccurringafterthethirddoseofpfizerbiontechcovid19vaccinecomplicationorcoincidenceanillustrativecasereportandliteraturereview
AT michałpiasecki trigeminalneuralgiaoccurringafterthethirddoseofpfizerbiontechcovid19vaccinecomplicationorcoincidenceanillustrativecasereportandliteraturereview
AT joannabielewicz trigeminalneuralgiaoccurringafterthethirddoseofpfizerbiontechcovid19vaccinecomplicationorcoincidenceanillustrativecasereportandliteraturereview