Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats

Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats

Abstract. Introduction:. Neuropathic pain (NP) affects countless people worldwide; however, few effective treatments are currently available. Histone deacetylases (HDACs) participate in epigenetic modifications in neuropathy-induced nociceptive sensitization. Gamma-aminobutyric acid (GABA) is a majo...

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Main Authors: Zhi-Hong Wen, Nan-Fu Chen, Hao-Jung Cheng, Hsiao-Mei Kuo, Pei-Yu Chen, Chien-Wei Feng, Zhi-Kang Yao, Wu-Fu Chen, Chun-Sung Sung
Format: Article
Language:English
Published: Wolters Kluwer 2024-12-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001209
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