Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians
Leukocytospermia, defined as a leukocyte concentration in semen exceeding 1×106 leukocytes/mL, significantly impacts male reproductive health by affecting sperm functionality and fertility outcomes. This condition arises from various etiological factors, including infections, autoimmune responses,...
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| Format: | Article |
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Korean Society for Sexual Medicine and Andrology
2025-07-01
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| Series: | The World Journal of Men's Health |
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| author | Sulagna Dutta Kadir Bocu Ashok Agarwal |
| author_facet | Sulagna Dutta Kadir Bocu Ashok Agarwal |
| author_sort | Sulagna Dutta |
| collection | DOAJ |
| description | Leukocytospermia, defined as a leukocyte concentration in semen exceeding 1×106 leukocytes/mL, significantly impacts
male reproductive health by affecting sperm functionality and fertility outcomes. This condition arises from various etiological
factors, including infections, autoimmune responses, lifestyle factors, and other physiological conditions. Adverse effects
on sperm associated with leukocytospermia include acrosome damage and abnormalities in the sperm midpiece and tail.
The review explores the complex interplay between leukocytospermia and oxidative stress, emphasizing the harmful effects
on sperm DNA integrity and overall sperm quality. Due to the multifactorial nature of leukocytospermia, diagnosing this condition
presents several challenges. Effective management strategies discussed include the use of antibiotics, anti-inflammatory
agents, and assisted reproductive technologies. Diagnostic methods range from traditional peroxidase staining to more advanced
techniques such as immunocytochemistry and flow cytometry, which offer higher sensitivity and specificity. Infections
of the male genital tract, particularly male accessory gland infection and male genital tract infection, play a significant
role in the etiology of leukocytospermia. These infections lead to an inflammatory response, resulting in leukocyte infiltration
into the semen. Systemic conditions like diabetes mellitus and autoimmune disorders also contribute to leukocytospermia
by provoking inflammatory responses that facilitate leukocyte presence in semen. This review underscores the importance
of a comprehensive diagnostic approach that includes patient history, physical examination, and advanced laboratory tests.
Treatment is tailored to the identified underlying cause, whether infectious or non-infectious. Lifestyle modifications, such
as reducing stress, improving diet, and avoiding environmental toxins, are also recommended to enhance semen quality. For
clinicians, this review provides a concise yet thorough overview of leukocytospermia, integrating the latest research findings
and clinical insights to aid in the effective management of this condition, ultimately aiming to improve patient care in male
reproductive health. |
| format | Article |
| id | doaj-art-12c74189eb274fb3ba26de0a87d0ed7f |
| institution | DOAJ |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-12c74189eb274fb3ba26de0a87d0ed7f2025-08-20T03:16:16ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-07-0143346547610.5534/wjmh.240152Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy CliniciansSulagna Dutta0https://orcid.org/0000-0002-7893-5282Kadir Bocu1https://orcid.org/0000-0003-4323-4037Ashok Agarwal2https://orcid.org/0000-0003-0585-1026Basic Medical Sciences Department, College of Medicine, Ajman University, Ajman, UAEGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USALeukocytospermia, defined as a leukocyte concentration in semen exceeding 1×106 leukocytes/mL, significantly impacts male reproductive health by affecting sperm functionality and fertility outcomes. This condition arises from various etiological factors, including infections, autoimmune responses, lifestyle factors, and other physiological conditions. Adverse effects on sperm associated with leukocytospermia include acrosome damage and abnormalities in the sperm midpiece and tail. The review explores the complex interplay between leukocytospermia and oxidative stress, emphasizing the harmful effects on sperm DNA integrity and overall sperm quality. Due to the multifactorial nature of leukocytospermia, diagnosing this condition presents several challenges. Effective management strategies discussed include the use of antibiotics, anti-inflammatory agents, and assisted reproductive technologies. Diagnostic methods range from traditional peroxidase staining to more advanced techniques such as immunocytochemistry and flow cytometry, which offer higher sensitivity and specificity. Infections of the male genital tract, particularly male accessory gland infection and male genital tract infection, play a significant role in the etiology of leukocytospermia. These infections lead to an inflammatory response, resulting in leukocyte infiltration into the semen. Systemic conditions like diabetes mellitus and autoimmune disorders also contribute to leukocytospermia by provoking inflammatory responses that facilitate leukocyte presence in semen. This review underscores the importance of a comprehensive diagnostic approach that includes patient history, physical examination, and advanced laboratory tests. Treatment is tailored to the identified underlying cause, whether infectious or non-infectious. Lifestyle modifications, such as reducing stress, improving diet, and avoiding environmental toxins, are also recommended to enhance semen quality. For clinicians, this review provides a concise yet thorough overview of leukocytospermia, integrating the latest research findings and clinical insights to aid in the effective management of this condition, ultimately aiming to improve patient care in male reproductive health.leukocytospermiainfertility; malemale genital tract infectionsoxidative stresssemen quality |
| spellingShingle | Sulagna Dutta Kadir Bocu Ashok Agarwal Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians The World Journal of Men's Health leukocytospermia infertility; male male genital tract infections oxidative stress semen quality |
| title | Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians |
| title_full | Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians |
| title_fullStr | Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians |
| title_full_unstemmed | Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians |
| title_short | Role of Leukocytospermia in the Management of Male Infertility: Decoding a Mystery for the Busy Clinicians |
| title_sort | role of leukocytospermia in the management of male infertility decoding a mystery for the busy clinicians |
| topic | leukocytospermia infertility; male male genital tract infections oxidative stress semen quality |
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