Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy
Following unilateral loss of vestibular input, recovery of motor symptoms is achieved within 2 weeks in rodents. Given that neurogenesis was only reported at 1 month post-lesion, whether there is neurogenesis in this early phase of vestibular compensation remains to be investigated. If not, what the...
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Elsevier
2025-06-01
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| author | Liang-Wei Chen Kenneth Lap-Kei Wu Kin-Wai Tam Chun-Wai Ma Yat-Ping Tsui Chun-Hong Lai Ying-Shing Chan Daisy Kwok-Yan Shum |
| author_facet | Liang-Wei Chen Kenneth Lap-Kei Wu Kin-Wai Tam Chun-Wai Ma Yat-Ping Tsui Chun-Hong Lai Ying-Shing Chan Daisy Kwok-Yan Shum |
| author_sort | Liang-Wei Chen |
| collection | DOAJ |
| description | Following unilateral loss of vestibular input, recovery of motor symptoms is achieved within 2 weeks in rodents. Given that neurogenesis was only reported at 1 month post-lesion, whether there is neurogenesis in this early phase of vestibular compensation remains to be investigated. If not, what then is the major cell type that participates in this timeframe? We show abundant nestin-positive cells in the ipsilesional but not contralesional vestibular nucleus (VN) of rats after ablating cell bodies of vestibular nerve at the Scarpa’s ganglion, as confirmed by both magnetic resonance imaging after surgery and histology. Bromodeoxyuridine (BrdU) uptake indicated that these cells actively proliferated. A high proportion of the cells were double-positive for nestin and GFAP as early as 4 days, and up to 2 weeks post-lesion, in contrast to none in control preparations. In contrast, the number of NeuN-positive neural lineage cells in the VN remained constant in both the control and lesioned rats. Furthermore, NeuN-positive cells were not positive for BrdU. However, a small number of proliferating cells stained positive for the immature neuron progenitor marker doublecortin. Taken together, we show that unilateral loss of vestibular input stimulates proliferation of neuroglial progenitors, and provide evidence that argues against occurrence of neurogenesis within the 2 week period in which recovery of postural and motor symptoms occurs. |
| format | Article |
| id | doaj-art-12b068c64fc7431d8bd61a53d9fd2500 |
| institution | DOAJ |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | IBRO Neuroscience Reports |
| spelling | doaj-art-12b068c64fc7431d8bd61a53d9fd25002025-08-20T03:20:56ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011869069710.1016/j.ibneur.2025.04.008Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomyLiang-Wei Chen0Kenneth Lap-Kei Wu1Kin-Wai Tam2Chun-Wai Ma3Yat-Ping Tsui4Chun-Hong Lai5Ying-Shing Chan6Daisy Kwok-Yan Shum7Institute of Neurosciences, The Fourth Military Medical University, Xi’an, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, China; Correspondence to: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong.School of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Brain & Cognitive Sciences, and The University of Hong Kong, Hong Kong, China; Neuroscience Research Centre, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Brain & Cognitive Sciences, and The University of Hong Kong, Hong Kong, China; Neuroscience Research Centre, The University of Hong Kong, Hong Kong, China; Correspondence to: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong.Following unilateral loss of vestibular input, recovery of motor symptoms is achieved within 2 weeks in rodents. Given that neurogenesis was only reported at 1 month post-lesion, whether there is neurogenesis in this early phase of vestibular compensation remains to be investigated. If not, what then is the major cell type that participates in this timeframe? We show abundant nestin-positive cells in the ipsilesional but not contralesional vestibular nucleus (VN) of rats after ablating cell bodies of vestibular nerve at the Scarpa’s ganglion, as confirmed by both magnetic resonance imaging after surgery and histology. Bromodeoxyuridine (BrdU) uptake indicated that these cells actively proliferated. A high proportion of the cells were double-positive for nestin and GFAP as early as 4 days, and up to 2 weeks post-lesion, in contrast to none in control preparations. In contrast, the number of NeuN-positive neural lineage cells in the VN remained constant in both the control and lesioned rats. Furthermore, NeuN-positive cells were not positive for BrdU. However, a small number of proliferating cells stained positive for the immature neuron progenitor marker doublecortin. Taken together, we show that unilateral loss of vestibular input stimulates proliferation of neuroglial progenitors, and provide evidence that argues against occurrence of neurogenesis within the 2 week period in which recovery of postural and motor symptoms occurs.http://www.sciencedirect.com/science/article/pii/S2667242125000569Neural progenitorsNestinVestibular compensationUnilateral vestibular neurectomy |
| spellingShingle | Liang-Wei Chen Kenneth Lap-Kei Wu Kin-Wai Tam Chun-Wai Ma Yat-Ping Tsui Chun-Hong Lai Ying-Shing Chan Daisy Kwok-Yan Shum Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy IBRO Neuroscience Reports Neural progenitors Nestin Vestibular compensation Unilateral vestibular neurectomy |
| title | Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy |
| title_full | Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy |
| title_fullStr | Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy |
| title_full_unstemmed | Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy |
| title_short | Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy |
| title_sort | gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy |
| topic | Neural progenitors Nestin Vestibular compensation Unilateral vestibular neurectomy |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000569 |
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