Diverse perspectives on proteomic posttranslational modifications to address EGFR-TKI resistance in non-small cell lung cancer

Diverse perspectives on proteomic posttranslational modifications to address EGFR-TKI resistance in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is the main histological subtype of lung cancer. For locally advanced and advanced NSCLC, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-targeted therapy has been the first choice for NSCLC patients with EGFR mutations. TKIs, as targeted dr...

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Bibliographic Details
Main Authors: Yuhong Ma, Feng Zhang, Jin Li, Juan Li, Yanhua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EGFR-TKI resistance
phosphorylation
autophosphorylation
glycosylation
crosstalk
NSCLC
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1436033/full
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