Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis
Introduction Heart diseases constitute a significant global public health concern. Cardiovascular diseases (CVDs) are characterised by disruptions in blood circulation and are notably prevalent among adults exposed to Westernised diets. Ginseng, a medicinal plant, has been recognised for its healing...
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BMJ Publishing Group
2024-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/7/e080926.full |
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| author | Sima Besharat Ali Jafari Kosar Kordkatuli Helia Mardani Fatemeh Mehdipoor Pardis Bakhtiari Jami Maryam Abbastabar Mohammadali Vakili Alireza Alaghi |
| author_facet | Sima Besharat Ali Jafari Kosar Kordkatuli Helia Mardani Fatemeh Mehdipoor Pardis Bakhtiari Jami Maryam Abbastabar Mohammadali Vakili Alireza Alaghi |
| author_sort | Sima Besharat |
| collection | DOAJ |
| description | Introduction Heart diseases constitute a significant global public health concern. Cardiovascular diseases (CVDs) are characterised by disruptions in blood circulation and are notably prevalent among adults exposed to Westernised diets. Ginseng, a medicinal plant, has been recognised for its healing properties and has a history of use spanning thousands of years. This systematic review aims to evaluate the efficacy of ginseng in modifying risk factors for CVD, including lipid profiles, glycaemic control, anthropometric indices, inflammation indicators, blood pressure, oxidative stress, liver function tests, adipokines and heart rate among individuals aged 18 and above, encompassing both genders.Methods and analysis We will conduct an electronic search for articles published from inception to September 2023 using a predefined search strategy in PubMed, Scopus, Web of Science, CENTRAL and EMBASE. Our search will focus exclusively on randomised controlled clinical trials involving both healthy and unhealthy participants. The process of reviewing articles, extracting pertinent information and assessing the quality of studies using the Cochrane risk of bias tool will be carried out independently by two reviewers. Any discrepancies will be resolved through discussion with a third party. If a sufficient number of eligible studies are identified, a meta-analysis will be conducted using these outcomes.Ethics and dissemination This study serves as the procedural framework for a comprehensive examination and does not require ethical approval. Additionally, the study adhered to the guidelines outlined in the Declaration of Helsinki. Ethical approval for the study was obtained from the Ethics Committee of Golestan University of Medical Sciences (IR.GOUMS.REC.1402.298).PROSPERO registration number CRD42023465688. |
| format | Article |
| id | doaj-art-12aac151dfc9402dbdb2388224fa6c67 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-12aac151dfc9402dbdb2388224fa6c672025-08-20T02:48:20ZengBMJ Publishing GroupBMJ Open2044-60552024-07-0114710.1136/bmjopen-2023-080926Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysisSima Besharat0Ali Jafari1Kosar Kordkatuli2Helia Mardani3Fatemeh Mehdipoor4Pardis Bakhtiari Jami5Maryam Abbastabar6Mohammadali Vakili7Alireza Alaghi88 Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran1 Student Research Committee, Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran4 Student Research Committee, Department of Public Health, School of Health, Golestan University of Medical Sciences, Gorgan, Iran1 Student Research Committee, Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran5 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran1 Student Research Committee, Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran6 Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran7 Health Management and Social Development Research Center, Department of Biostatistics and Epidemiology, Golestan University of Medical Sciences, Gorgan, Iran2 Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, IranIntroduction Heart diseases constitute a significant global public health concern. Cardiovascular diseases (CVDs) are characterised by disruptions in blood circulation and are notably prevalent among adults exposed to Westernised diets. Ginseng, a medicinal plant, has been recognised for its healing properties and has a history of use spanning thousands of years. This systematic review aims to evaluate the efficacy of ginseng in modifying risk factors for CVD, including lipid profiles, glycaemic control, anthropometric indices, inflammation indicators, blood pressure, oxidative stress, liver function tests, adipokines and heart rate among individuals aged 18 and above, encompassing both genders.Methods and analysis We will conduct an electronic search for articles published from inception to September 2023 using a predefined search strategy in PubMed, Scopus, Web of Science, CENTRAL and EMBASE. Our search will focus exclusively on randomised controlled clinical trials involving both healthy and unhealthy participants. The process of reviewing articles, extracting pertinent information and assessing the quality of studies using the Cochrane risk of bias tool will be carried out independently by two reviewers. Any discrepancies will be resolved through discussion with a third party. If a sufficient number of eligible studies are identified, a meta-analysis will be conducted using these outcomes.Ethics and dissemination This study serves as the procedural framework for a comprehensive examination and does not require ethical approval. Additionally, the study adhered to the guidelines outlined in the Declaration of Helsinki. Ethical approval for the study was obtained from the Ethics Committee of Golestan University of Medical Sciences (IR.GOUMS.REC.1402.298).PROSPERO registration number CRD42023465688.https://bmjopen.bmj.com/content/14/7/e080926.full |
| spellingShingle | Sima Besharat Ali Jafari Kosar Kordkatuli Helia Mardani Fatemeh Mehdipoor Pardis Bakhtiari Jami Maryam Abbastabar Mohammadali Vakili Alireza Alaghi Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis BMJ Open |
| title | Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis |
| title_full | Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis |
| title_fullStr | Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis |
| title_full_unstemmed | Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis |
| title_short | Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis |
| title_sort | ginseng supplementation and cardiovascular disease risk factors a protocol for grade assessed systematic review and dose response meta analysis |
| url | https://bmjopen.bmj.com/content/14/7/e080926.full |
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