Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections
Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in human...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2010/124509 |
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| author | Andreas F. Haag Kamila K. Myka Markus F. F. Arnold Paola Caro-Hernández Gail P. Ferguson |
| author_facet | Andreas F. Haag Kamila K. Myka Markus F. F. Arnold Paola Caro-Hernández Gail P. Ferguson |
| author_sort | Andreas F. Haag |
| collection | DOAJ |
| description | Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans. Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the Brucella cell envelope play an important role in their host interaction. Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic β-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development. |
| format | Article |
| id | doaj-art-12a83efff48148cdb2078b8b020522e9 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-12a83efff48148cdb2078b8b020522e92025-02-03T05:51:14ZengWileyInternational Journal of Microbiology1687-918X1687-91982010-01-01201010.1155/2010/124509124509Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian InfectionsAndreas F. Haag0Kamila K. Myka1Markus F. F. Arnold2Paola Caro-Hernández3Gail P. Ferguson4School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UKSchool of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UKSchool of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UKSchool of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UKSchool of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UKBrucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans. Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the Brucella cell envelope play an important role in their host interaction. Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic β-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.http://dx.doi.org/10.1155/2010/124509 |
| spellingShingle | Andreas F. Haag Kamila K. Myka Markus F. F. Arnold Paola Caro-Hernández Gail P. Ferguson Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections International Journal of Microbiology |
| title | Importance of Lipopolysaccharide and Cyclic
β-1,2-Glucans in Brucella-Mammalian Infections |
| title_full | Importance of Lipopolysaccharide and Cyclic
β-1,2-Glucans in Brucella-Mammalian Infections |
| title_fullStr | Importance of Lipopolysaccharide and Cyclic
β-1,2-Glucans in Brucella-Mammalian Infections |
| title_full_unstemmed | Importance of Lipopolysaccharide and Cyclic
β-1,2-Glucans in Brucella-Mammalian Infections |
| title_short | Importance of Lipopolysaccharide and Cyclic
β-1,2-Glucans in Brucella-Mammalian Infections |
| title_sort | importance of lipopolysaccharide and cyclic β 1 2 glucans in brucella mammalian infections |
| url | http://dx.doi.org/10.1155/2010/124509 |
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