Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis
Aim. Investigation of hepatic microhaemocirculation effects in experimental extrahepatic cholestasis.Materials and Methods. Experiments were carried out with a mixed group of 48 white mongrel male rats. Extrahepatic cholestasis was modelled in rats with via the ligation of common bile duct.Results. A...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2020-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/459 |
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| author | K. Kh. Akhmedov M. A. Ergashev A. N. Meliboboyev E. H. Boltayev |
| author_facet | K. Kh. Akhmedov M. A. Ergashev A. N. Meliboboyev E. H. Boltayev |
| author_sort | K. Kh. Akhmedov |
| collection | DOAJ |
| description | Aim. Investigation of hepatic microhaemocirculation effects in experimental extrahepatic cholestasis.Materials and Methods. Experiments were carried out with a mixed group of 48 white mongrel male rats. Extrahepatic cholestasis was modelled in rats with via the ligation of common bile duct.Results. Animals with ligated common bile duct showed abnormalities in peripheral hepatic circulation manifested by a complex of intravascular, vascular and paravascular changes, hepatic angioarchitectonics disturbance, a marked growth of parenchymal dystrophic lesions in the form of post-haemorrhagic foci. The disturbance was pronounced towards a virtual degradation of hepatic parenchyma and the growth of “numb” zones with ceased circulation.Conclusion. The trials revealed microcirculatory changes in the liver associated with rheological disturbance of blood and, subsequently, the toxic impact of failed metabolism. |
| format | Article |
| id | doaj-art-129b0dca46ca4e9ea7808afc072822bb |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-129b0dca46ca4e9ea7808afc072822bb2025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-12-01306455010.22416/1382-4376-2020-30-6-45-50401Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic CholestasisK. Kh. Akhmedov0M. A. Ergashev1A. N. Meliboboyev2E. H. Boltayev3Termez Branch of the Tashkent Medical AcademyTermez Branch of the Tashkent Medical AcademyTermez Branch of the Tashkent Medical AcademyTermez Branch of the Tashkent Medical AcademyAim. Investigation of hepatic microhaemocirculation effects in experimental extrahepatic cholestasis.Materials and Methods. Experiments were carried out with a mixed group of 48 white mongrel male rats. Extrahepatic cholestasis was modelled in rats with via the ligation of common bile duct.Results. Animals with ligated common bile duct showed abnormalities in peripheral hepatic circulation manifested by a complex of intravascular, vascular and paravascular changes, hepatic angioarchitectonics disturbance, a marked growth of parenchymal dystrophic lesions in the form of post-haemorrhagic foci. The disturbance was pronounced towards a virtual degradation of hepatic parenchyma and the growth of “numb” zones with ceased circulation.Conclusion. The trials revealed microcirculatory changes in the liver associated with rheological disturbance of blood and, subsequently, the toxic impact of failed metabolism.https://www.gastro-j.ru/jour/article/view/459cholestasismicrocirculationangioarchitectonics |
| spellingShingle | K. Kh. Akhmedov M. A. Ergashev A. N. Meliboboyev E. H. Boltayev Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis Российский журнал гастроэнтерологии, гепатологии, колопроктологии cholestasis microcirculation angioarchitectonics |
| title | Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis |
| title_full | Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis |
| title_fullStr | Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis |
| title_full_unstemmed | Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis |
| title_short | Hepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis |
| title_sort | hepatic microhaemocirculation dynamics in experimental extrahepatic cholestasis |
| topic | cholestasis microcirculation angioarchitectonics |
| url | https://www.gastro-j.ru/jour/article/view/459 |
| work_keys_str_mv | AT kkhakhmedov hepaticmicrohaemocirculationdynamicsinexperimentalextrahepaticcholestasis AT maergashev hepaticmicrohaemocirculationdynamicsinexperimentalextrahepaticcholestasis AT anmeliboboyev hepaticmicrohaemocirculationdynamicsinexperimentalextrahepaticcholestasis AT ehboltayev hepaticmicrohaemocirculationdynamicsinexperimentalextrahepaticcholestasis |