Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients
Objective To explore the relationship between xanthine oxidoreductase(XOR)activity and kidney injury in patients with chronic kidney disease(CKD).Methods A total of 105 patients with CKD were selected as the research objects in this study.We measured plasma XOR and xanthine oxidase(XO)activities,and...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2020-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57906492&Fpath=home&index=0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187251590365184 |
|---|---|
| author | ZHANG Yi-yuan ZHAO Ming-yue WEI Juan-yu ZHANG Shuai XU Meng ZHENG Dong-hui |
| author_facet | ZHANG Yi-yuan ZHAO Ming-yue WEI Juan-yu ZHANG Shuai XU Meng ZHENG Dong-hui |
| author_sort | ZHANG Yi-yuan |
| collection | DOAJ |
| description | Objective To explore the relationship between xanthine oxidoreductase(XOR)activity and kidney injury in patients with chronic kidney disease(CKD).Methods A total of 105 patients with CKD were selected as the research objects in this study.We measured plasma XOR and xanthine oxidase(XO)activities,and calculated the ratio of XO/XOR.Those patients’ clinical data were collected,including sex,age,diastolic blood pressure(DBP),fasting blood glucose(FBG),triglyceride(TG),estimated glomerular filtration rate(eGFR),serum potassium,serum calcium,serum phosphorus,and blood chlorine.We used correlation analysis to analyze the relationship between the XOR,XO,XO/XOR ratio and clinical data of CKD patients.Multivariate linear regression analysis was used to explore the influencing factors of XOR,XO,XO/XOR ratio.Results Plasma XOR activity was positively correlated with eGFR,DBP,FBG,GGT,and negatively correlated with age,Cl~-(P<0.05).Plasma XO activity was positively related to FBG,GGT,TBil,TG,and negatively correlated with Cl~-(P<0.05).XO/XOR ratio was positively correlated with age,BUN,and negatively correlated with eGFR(P<0.05).Multiple linear regression analysis showed that eGFR,FBG and DBP were independent factors significantly associated with XOR(P<0.05),FBG and GGT were independent influencing factors of plasma XO activity(P<0.05),and eGFR was independent Influencing factors of plasma XO/XOR ratio(P<0.05).Conclusions Controlling the levels of FBG and DBP in CKD patients is beneficial to reduce the plasma XOR activity in CKD patients.So,developing a new drug to inhibit XOR activity without affecting UA production may provide a new therapy to delay the CKD progression. |
| format | Article |
| id | doaj-art-1296535c26bf4c6c992083096c28cf50 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2020-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-1296535c26bf4c6c992083096c28cf502025-08-20T02:16:10ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902020-01-0162563057906492Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patientsZHANG Yi-yuanZHAO Ming-yueWEI Juan-yuZHANG ShuaiXU MengZHENG Dong-huiObjective To explore the relationship between xanthine oxidoreductase(XOR)activity and kidney injury in patients with chronic kidney disease(CKD).Methods A total of 105 patients with CKD were selected as the research objects in this study.We measured plasma XOR and xanthine oxidase(XO)activities,and calculated the ratio of XO/XOR.Those patients’ clinical data were collected,including sex,age,diastolic blood pressure(DBP),fasting blood glucose(FBG),triglyceride(TG),estimated glomerular filtration rate(eGFR),serum potassium,serum calcium,serum phosphorus,and blood chlorine.We used correlation analysis to analyze the relationship between the XOR,XO,XO/XOR ratio and clinical data of CKD patients.Multivariate linear regression analysis was used to explore the influencing factors of XOR,XO,XO/XOR ratio.Results Plasma XOR activity was positively correlated with eGFR,DBP,FBG,GGT,and negatively correlated with age,Cl~-(P<0.05).Plasma XO activity was positively related to FBG,GGT,TBil,TG,and negatively correlated with Cl~-(P<0.05).XO/XOR ratio was positively correlated with age,BUN,and negatively correlated with eGFR(P<0.05).Multiple linear regression analysis showed that eGFR,FBG and DBP were independent factors significantly associated with XOR(P<0.05),FBG and GGT were independent influencing factors of plasma XO activity(P<0.05),and eGFR was independent Influencing factors of plasma XO/XOR ratio(P<0.05).Conclusions Controlling the levels of FBG and DBP in CKD patients is beneficial to reduce the plasma XOR activity in CKD patients.So,developing a new drug to inhibit XOR activity without affecting UA production may provide a new therapy to delay the CKD progression.http://www.lcszb.com/thesisDetails?columnId=57906492&Fpath=home&index=0Xanthine oxidoreductaseXanthine oxidaseReactive oxygen speciesChronic kidney disease |
| spellingShingle | ZHANG Yi-yuan ZHAO Ming-yue WEI Juan-yu ZHANG Shuai XU Meng ZHENG Dong-hui Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients Linchuang shenzangbing zazhi Xanthine oxidoreductase Xanthine oxidase Reactive oxygen species Chronic kidney disease |
| title | Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients |
| title_full | Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients |
| title_fullStr | Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients |
| title_full_unstemmed | Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients |
| title_short | Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients |
| title_sort | relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients |
| topic | Xanthine oxidoreductase Xanthine oxidase Reactive oxygen species Chronic kidney disease |
| url | http://www.lcszb.com/thesisDetails?columnId=57906492&Fpath=home&index=0 |
| work_keys_str_mv | AT zhangyiyuan relationshipbetweenxanthineoxidoreductaseandrenaldamageinchronickidneydiseasepatients AT zhaomingyue relationshipbetweenxanthineoxidoreductaseandrenaldamageinchronickidneydiseasepatients AT weijuanyu relationshipbetweenxanthineoxidoreductaseandrenaldamageinchronickidneydiseasepatients AT zhangshuai relationshipbetweenxanthineoxidoreductaseandrenaldamageinchronickidneydiseasepatients AT xumeng relationshipbetweenxanthineoxidoreductaseandrenaldamageinchronickidneydiseasepatients AT zhengdonghui relationshipbetweenxanthineoxidoreductaseandrenaldamageinchronickidneydiseasepatients |