Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India
PURPOSEBuccal mucosa cancer (BMC), the most prevalent oral cancer (OC) site, is a multifactorial disease. With relatively high prevalence of periodontal diseases because of poor oral hygiene practices, oral health indicators remain an area of exploration in the Indian context for its association wit...
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2025-07-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO-25-00119 |
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| author | Grace Sarah George Arjun Singh Romi Moirangthem Aniket Patil Gayathri B. Pullat Sakshi Sagare Manigreeva Krishnatreya Aseem Mishra Rahul Sonwane Bayan Hosseini Anil Chaturvedi Pankaj Chaturvedi Rajesh Dikshit Sharayu Mhatre |
| author_facet | Grace Sarah George Arjun Singh Romi Moirangthem Aniket Patil Gayathri B. Pullat Sakshi Sagare Manigreeva Krishnatreya Aseem Mishra Rahul Sonwane Bayan Hosseini Anil Chaturvedi Pankaj Chaturvedi Rajesh Dikshit Sharayu Mhatre |
| author_sort | Grace Sarah George |
| collection | DOAJ |
| description | PURPOSEBuccal mucosa cancer (BMC), the most prevalent oral cancer (OC) site, is a multifactorial disease. With relatively high prevalence of periodontal diseases because of poor oral hygiene practices, oral health indicators remain an area of exploration in the Indian context for its association with BMC.METHODSA total of 1,673 histologically confirmed cases and 1,601 frequency-matched controls from a hospital-based, multicenter case-control study was analyzed for the risk of BMC because of the oral hygiene indicators—denture use, number of decayed, missing, and filled teeth, and the Decayed, Missing, Filled Teeth (DMFT) score. Logistic regression models, adjusted for potential confounders like age, sex, rural-urban status, education, and tobacco and alcohol use (duration and frequency), were used to estimate odds ratios (ORs) and 95% CI. Analysis was further stratified on tobacco chewing and smoking.RESULTSWe obtained an increased risk of decayed (OR>2 decayed teeth, 1.53; 95% CI, 1.09 to 2.16), missing teeth (OR>2 missing teeth, 2.59; 95% CI, 1.99 to 3.37), and high DMFT scores (OR>3 DMFT score, 2.07; 95% CI, 1.62 to 2.66). Similar results were observed on the stratified analysis. Protective effect was observed for teeth filling (OR>2 teeth-fillings, 0.59; 95% CI, 0.34 to 1.03) and denture use (ORever versus never used dentures, 0.63; 95% CI, 0.47 to 0.85).CONCLUSIONOur findings suggest that DMFT score is associated with the risk of BMC and should be included in national oral health programs for prevention of OCs, along with other indicators of oral hygiene. |
| format | Article |
| id | doaj-art-12957f032c634f6982f6d12c253aeec2 |
| institution | Kabale University |
| issn | 2687-8941 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj-art-12957f032c634f6982f6d12c253aeec22025-08-20T03:55:58ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412025-07-011110.1200/GO-25-00119Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From IndiaGrace Sarah George0Arjun Singh1Romi Moirangthem2Aniket Patil3Gayathri B. Pullat4Sakshi Sagare5Manigreeva Krishnatreya6Aseem Mishra7Rahul Sonwane8Bayan Hosseini9Anil Chaturvedi10Pankaj Chaturvedi11Rajesh Dikshit12Sharayu Mhatre13Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaHomi Bhabha National Institute (HBNI), Mumbai, IndiaDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaDr B. Borooah Cancer Institute—Tata Memorial Centre, Guwahati, IndiaHomi Bhabha National Institute (HBNI), Mumbai, IndiaCentre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, World Health Organisation, Lyon, FranceDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MDHomi Bhabha National Institute (HBNI), Mumbai, IndiaHomi Bhabha National Institute (HBNI), Mumbai, IndiaDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, IndiaPURPOSEBuccal mucosa cancer (BMC), the most prevalent oral cancer (OC) site, is a multifactorial disease. With relatively high prevalence of periodontal diseases because of poor oral hygiene practices, oral health indicators remain an area of exploration in the Indian context for its association with BMC.METHODSA total of 1,673 histologically confirmed cases and 1,601 frequency-matched controls from a hospital-based, multicenter case-control study was analyzed for the risk of BMC because of the oral hygiene indicators—denture use, number of decayed, missing, and filled teeth, and the Decayed, Missing, Filled Teeth (DMFT) score. Logistic regression models, adjusted for potential confounders like age, sex, rural-urban status, education, and tobacco and alcohol use (duration and frequency), were used to estimate odds ratios (ORs) and 95% CI. Analysis was further stratified on tobacco chewing and smoking.RESULTSWe obtained an increased risk of decayed (OR>2 decayed teeth, 1.53; 95% CI, 1.09 to 2.16), missing teeth (OR>2 missing teeth, 2.59; 95% CI, 1.99 to 3.37), and high DMFT scores (OR>3 DMFT score, 2.07; 95% CI, 1.62 to 2.66). Similar results were observed on the stratified analysis. Protective effect was observed for teeth filling (OR>2 teeth-fillings, 0.59; 95% CI, 0.34 to 1.03) and denture use (ORever versus never used dentures, 0.63; 95% CI, 0.47 to 0.85).CONCLUSIONOur findings suggest that DMFT score is associated with the risk of BMC and should be included in national oral health programs for prevention of OCs, along with other indicators of oral hygiene.https://ascopubs.org/doi/10.1200/GO-25-00119 |
| spellingShingle | Grace Sarah George Arjun Singh Romi Moirangthem Aniket Patil Gayathri B. Pullat Sakshi Sagare Manigreeva Krishnatreya Aseem Mishra Rahul Sonwane Bayan Hosseini Anil Chaturvedi Pankaj Chaturvedi Rajesh Dikshit Sharayu Mhatre Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India JCO Global Oncology |
| title | Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India |
| title_full | Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India |
| title_fullStr | Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India |
| title_full_unstemmed | Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India |
| title_short | Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India |
| title_sort | association of decayed missing filled teeth score with the risk for buccal mucosa cancer stratified on tobacco and alcohol use a multicenter case control study from india |
| url | https://ascopubs.org/doi/10.1200/GO-25-00119 |
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