Mitogen-Activated Protein Kinase Kinase Kinase 1 Overexpression Disrupts Development of the Ocular Surface Epithelium

Mitogen-Activated Protein Kinase Kinase Kinase 1 Overexpression Disrupts Development of the Ocular Surface Epithelium

Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) is a key signaling molecule essential for eyelid closure during embryogenesis. In mice, <i>Map3k1</i> knockout leads to a fully penetrant eye-open at birth (EOB) phenotype due to disrupted MAPK signaling, abnormal epithelial diffe...

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Bibliographic Details
Main Authors: Maureen Mongan, Bo Xiao, Antonius Christianto, Yueh-Chiang Hu, Ying Xia
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
MAP3K1 gain-of-function
ocular surface epithelium
eyelid closure
epithelial morphogenesis
Online Access:https://www.mdpi.com/2073-4409/14/12/894
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