Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis

Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis

Abstract Bony fusion caused by pathological new bone formation manifests the clinical feature of ankylosing spondylitis (AS). However, the underlying mechanism remains elusive. Here we discovered spontaneous kyphosis, arthritis and bony fusion in mature CD4-Cre;Ptpn11 f/f mice, which present the pat...

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Main Authors: Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26750-6
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