The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common multi-factorial liver disease, and its incidence is gradually increasing worldwide. Many reports have revealed that intestinal flora plays a crucial role for the occurrence and development of MASLD, through mechanisms such...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1490929/full |
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| author | Li Jun Wang Jian Guang Sun Shu Cheng Chen Yu Li Sun Yang Zheng Jian Chao Feng |
| author_facet | Li Jun Wang Jian Guang Sun Shu Cheng Chen Yu Li Sun Yang Zheng Jian Chao Feng |
| author_sort | Li Jun Wang |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common multi-factorial liver disease, and its incidence is gradually increasing worldwide. Many reports have revealed that intestinal flora plays a crucial role for the occurrence and development of MASLD, through mechanisms such as flora translocation, endogenous ethanol production, dysregulation of choline metabolism and bile acid, and endotoxemia. Here, we review the relationship between intestinal flora and MASLD, as well as interventions for MASLD, such as prebiotics, probiotics, synbiotics, and intestinal flora transplantation. Intervention strategies targeting the intestinal flora along with its metabolites may be new targets for preventing and treating MASLD. |
| format | Article |
| id | doaj-art-1284e0fb259e478ca01d4eb4851c496b |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-1284e0fb259e478ca01d4eb4851c496b2025-01-07T05:23:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14909291490929The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategiesLi Jun Wang0Jian Guang Sun1Shu Cheng Chen2Yu Li Sun3Yang Zheng4Jian Chao Feng5Department of Traditional Chinese Medicine, Binzhou Medical University, Yantai, ChinaThe First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaDepartment of Hepatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Acupuncture and Moxibustion, Zibo Hospital, Zibo, ChinaDepartment of Acupuncture and Moxibustion, Zibo Hospital, Zibo, ChinaMetabolic dysfunction-associated steatotic liver disease (MASLD) is a common multi-factorial liver disease, and its incidence is gradually increasing worldwide. Many reports have revealed that intestinal flora plays a crucial role for the occurrence and development of MASLD, through mechanisms such as flora translocation, endogenous ethanol production, dysregulation of choline metabolism and bile acid, and endotoxemia. Here, we review the relationship between intestinal flora and MASLD, as well as interventions for MASLD, such as prebiotics, probiotics, synbiotics, and intestinal flora transplantation. Intervention strategies targeting the intestinal flora along with its metabolites may be new targets for preventing and treating MASLD.https://www.frontiersin.org/articles/10.3389/fmed.2024.1490929/fullintestinal florametabolic dysfunction-associated steatotic liver diseaseprobioticsmetabolismreview |
| spellingShingle | Li Jun Wang Jian Guang Sun Shu Cheng Chen Yu Li Sun Yang Zheng Jian Chao Feng The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies Frontiers in Medicine intestinal flora metabolic dysfunction-associated steatotic liver disease probiotics metabolism review |
| title | The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies |
| title_full | The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies |
| title_fullStr | The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies |
| title_full_unstemmed | The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies |
| title_short | The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies |
| title_sort | role of intestinal flora in metabolic dysfunction associated steatotic liver disease and treatment strategies |
| topic | intestinal flora metabolic dysfunction-associated steatotic liver disease probiotics metabolism review |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1490929/full |
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