Efficacy of <i>Stenocereus queretaroensis</i>-Derived Silver Nanoparticles Against Methicillin-Resistant <i>Staphylococcus aureus</i> Biofilms: Synthesis and Antibiofilm Activity

Efficacy of <i>Stenocereus queretaroensis</i>-Derived Silver Nanoparticles Against Methicillin-Resistant <i>Staphylococcus aureus</i> Biofilms: Synthesis and Antibiofilm Activity

Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is responsible for many infections, primarily due to its ability to form biofilms. Nanotechnology has recently been proposed as an alternative for controlling MRSA. In the present work, we evaluated the antimicrobial and antibiofi...

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Main Authors: Angélica Sofía González-Garibay, Iván Moisés Sánchez-Hernández, Ariadna Abigail Villarreal-Amézquita, Omar Ricardo Torres-González, Eduardo Padilla-Camberos
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Inorganics
Subjects:
antibiofilm
metallic nanoparticles
antibiotic resistance
Online Access:https://www.mdpi.com/2304-6740/13/6/178
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Summary:Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is responsible for many infections, primarily due to its ability to form biofilms. Nanotechnology has recently been proposed as an alternative for controlling MRSA. In the present work, we evaluated the antimicrobial and antibiofilm activities of silver nanoparticles synthesized with <i>Stenocereus queretaroensis</i> peel extract (SAgNPs). The biosynthesis process was optimized using a response surface design. The results showed antimicrobial activity against MRSA bacteria, with a minimum inhibitory concentration and minimum bactericidal concentration of 0.15 and 0.31 µg/mL, respectively. SAgNPs inhibited biofilm formation in multi-well plates and Congo red agar. Molecular docking analysis revealed that the presence of quercetin, one of the chemical components of <i>S. queretaroensis</i> peel, forms hydrogen bonds with six interacting amino acids. This suggests that quercetin presents a stable binding to this site, which in turn suggests that the mechanism of action of SAgNPs is related to their binding to PBP2a. Therefore, these findings suggest a promising, environmentally friendly approach to combating antibiotic-resistant infections, potentially reducing the reliance on traditional antibiotics.
ISSN:2304-6740

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