Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature
Thyroid cancers are the most common endocrine organ cancers. Encapsulated follicular variant papillary thyroid carcinomas (EFVPTC) are quite slow (indolent). Non-invasive follicular thyroid neoplasm with papillary nuclear feature (NIFTP) is a new entity identified as a result of studies in recent ye...
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Termedia Publishing House
2024-12-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/Morphological-and-immunohistochemical-analysis-in-encapsulated-follicular-variant-papillary-thyroid-carcinoma-invasive-follicular-variant-papillary-thyroid-carcinoma-and-a-new-entity-non-invasive-foll,55,55288,1,1.html |
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| author | Zeliha Çelik Naile Kökbudak Fahriye Kilinç Pembe Oltulu |
| author_facet | Zeliha Çelik Naile Kökbudak Fahriye Kilinç Pembe Oltulu |
| author_sort | Zeliha Çelik |
| collection | DOAJ |
| description | Thyroid cancers are the most common endocrine organ cancers. Encapsulated follicular variant papillary thyroid carcinomas (EFVPTC) are quite slow (indolent). Non-invasive follicular thyroid neoplasm with papillary nuclear feature (NIFTP) is a new entity identified as a result of studies in recent years. If the patient instead of EFVPTC develops NIFTP, cancer will not be recognized and the treatment will change.
Three groups, in which CD44, p53, Ki-67, p27, HBME-1, galectin-3, cytokeratin-19, CD56 were used as markers, were evaluated. Nuclear score assessment was also conducted in the NIFTP group. The results were compared with each other.
Significant differences were detected in the intensities and percentages of CK19, HBME-1, CD56, CD44 staining and galectin-3 staining intensity. In group 1, cytokeratin-19, galectin-3, HBME-1 and CD44 expression were not as low as in the other groups, while CD56 staining was detected more frequently. p53, p27 and Ki-67 staining showed no obvious expression differences between the groups.
The NIFTP group showed different IHC results compared to encapsulated invasive FVPTC and common invasive FVPTC. When evaluating whether the IHC expression patterns used in PTCs differ in NIFTP cases, it was found that CD44 could serve as an additional IHC stain that may guide pathologists during the diagnosis. |
| format | Article |
| id | doaj-art-128192095d7c41ebaf1902300cc6e773 |
| institution | Kabale University |
| issn | 1233-9687 2084-9869 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj-art-128192095d7c41ebaf1902300cc6e7732025-01-27T11:36:31ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692024-12-0175431532310.5114/pjp.2024.14569655288Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear featureZeliha ÇelikNaile KökbudakFahriye KilinçPembe OltuluThyroid cancers are the most common endocrine organ cancers. Encapsulated follicular variant papillary thyroid carcinomas (EFVPTC) are quite slow (indolent). Non-invasive follicular thyroid neoplasm with papillary nuclear feature (NIFTP) is a new entity identified as a result of studies in recent years. If the patient instead of EFVPTC develops NIFTP, cancer will not be recognized and the treatment will change. Three groups, in which CD44, p53, Ki-67, p27, HBME-1, galectin-3, cytokeratin-19, CD56 were used as markers, were evaluated. Nuclear score assessment was also conducted in the NIFTP group. The results were compared with each other. Significant differences were detected in the intensities and percentages of CK19, HBME-1, CD56, CD44 staining and galectin-3 staining intensity. In group 1, cytokeratin-19, galectin-3, HBME-1 and CD44 expression were not as low as in the other groups, while CD56 staining was detected more frequently. p53, p27 and Ki-67 staining showed no obvious expression differences between the groups. The NIFTP group showed different IHC results compared to encapsulated invasive FVPTC and common invasive FVPTC. When evaluating whether the IHC expression patterns used in PTCs differ in NIFTP cases, it was found that CD44 could serve as an additional IHC stain that may guide pathologists during the diagnosis.https://www.termedia.pl/Morphological-and-immunohistochemical-analysis-in-encapsulated-follicular-variant-papillary-thyroid-carcinoma-invasive-follicular-variant-papillary-thyroid-carcinoma-and-a-new-entity-non-invasive-foll,55,55288,1,1.htmlp53 ki67 cd44 niftp thyroid |
| spellingShingle | Zeliha Çelik Naile Kökbudak Fahriye Kilinç Pembe Oltulu Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature Polish Journal of Pathology p53 ki67 cd44 niftp thyroid |
| title | Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature |
| title_full | Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature |
| title_fullStr | Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature |
| title_full_unstemmed | Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature |
| title_short | Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature |
| title_sort | morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma invasive follicular variant papillary thyroid carcinoma and a new entity non invasive follicular thyroid neoplasm with papillary nuclear feature |
| topic | p53 ki67 cd44 niftp thyroid |
| url | https://www.termedia.pl/Morphological-and-immunohistochemical-analysis-in-encapsulated-follicular-variant-papillary-thyroid-carcinoma-invasive-follicular-variant-papillary-thyroid-carcinoma-and-a-new-entity-non-invasive-foll,55,55288,1,1.html |
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