Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications

Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications

Abstract CNS tumours encompass a diverse group of neoplasms with significant morbidity and mortality. The SHH signalling pathway plays a critical role in the pathogenesis of several CNS tumours, including gliomas, medulloblastomas and others. By influencing cellular proliferation, differentiation an...

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Main Authors: Andrew Awuah Wireko, Adam Ben-Jaafar, Jonathan Sing Huk Kong, Krishitha Meenu Mannan, Vivek Sanker, Sophie-Liliane Rosenke, Allswell Naa Adjeley Boye, Princess Afia Nkrumah-Boateng, Jeisun Poornaselvan, Muhammad Hamza Shah, Toufik Abdul-Rahman, Oday Atallah
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Brain
Subjects:
Sonic Hedgehog signalling pathway
Brain tumours
Molecular neuro-oncology
Neuro-genetics
Online Access:https://doi.org/10.1186/s13041-024-01155-w
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