Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study
Abstract Objective The weight-adjusted-waist index (WWI) is a novel obesity measurement indicator, and this study aims to determine the relationship between WWI and Familial hypercholesterolemia (FH). Methods Using data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04293-0 |
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| author | Xuan Lyu Xuanxuan Ren Weiqing Zhang Hanqin Zhu Yu Wang Jiarou Qiu Fangying Wu Sisi Xu Zhaokai Jin Minchun Yang |
| author_facet | Xuan Lyu Xuanxuan Ren Weiqing Zhang Hanqin Zhu Yu Wang Jiarou Qiu Fangying Wu Sisi Xu Zhaokai Jin Minchun Yang |
| author_sort | Xuan Lyu |
| collection | DOAJ |
| description | Abstract Objective The weight-adjusted-waist index (WWI) is a novel obesity measurement indicator, and this study aims to determine the relationship between WWI and Familial hypercholesterolemia (FH). Methods Using data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to March 2020, cross-sectional data from 3698 participants were analyzed. The study examined the correlation between WWI and FH using multivariate logistic regression and smooth curve fitting, and conducted subgroup analysis and interaction tests. Results The study sample consisted of 3698 subjects for whom the overall probable prevalence of FH was 5.43% and increased with WWI tertile (quantile 1: 4.00%; quantile 2: 4.94%; quantile 3: 7.34%); individuals with the highest WWI tertile were significantly more likely to have FH than those with the lowest tertile (OR = 4.60,95% CI: 2.00-10.60). Subgroup analysis and interaction tests showed significant significance between WWI and personal history of early Atherosclerotic cardiovascular disease (ASCVD), family history of early ASCVD and probable prevalence of FH (p < 0.05). Conclusion This study demonstrates a nonlinear positive correlation between WWI and FH. This may provide new ideas for the prevention and treatment of FH in the future. |
| format | Article |
| id | doaj-art-127e5a9f02e2428399429235a9d36c74 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-127e5a9f02e2428399429235a9d36c742024-11-17T12:08:49ZengBMCBMC Cardiovascular Disorders1471-22612024-11-012411910.1186/s12872-024-04293-0Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional studyXuan Lyu0Xuanxuan Ren1Weiqing Zhang2Hanqin Zhu3Yu Wang4Jiarou Qiu5Fangying Wu6Sisi Xu7Zhaokai Jin8Minchun Yang9Zhejiang Chinese Medical UniversityZhejiang HospitalZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityHangzhou City UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang HospitalAbstract Objective The weight-adjusted-waist index (WWI) is a novel obesity measurement indicator, and this study aims to determine the relationship between WWI and Familial hypercholesterolemia (FH). Methods Using data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to March 2020, cross-sectional data from 3698 participants were analyzed. The study examined the correlation between WWI and FH using multivariate logistic regression and smooth curve fitting, and conducted subgroup analysis and interaction tests. Results The study sample consisted of 3698 subjects for whom the overall probable prevalence of FH was 5.43% and increased with WWI tertile (quantile 1: 4.00%; quantile 2: 4.94%; quantile 3: 7.34%); individuals with the highest WWI tertile were significantly more likely to have FH than those with the lowest tertile (OR = 4.60,95% CI: 2.00-10.60). Subgroup analysis and interaction tests showed significant significance between WWI and personal history of early Atherosclerotic cardiovascular disease (ASCVD), family history of early ASCVD and probable prevalence of FH (p < 0.05). Conclusion This study demonstrates a nonlinear positive correlation between WWI and FH. This may provide new ideas for the prevention and treatment of FH in the future.https://doi.org/10.1186/s12872-024-04293-0Cross-sectional studyWeight-adjusted-waist indexFamilial hypercholesterolaemiaObesityNHANES |
| spellingShingle | Xuan Lyu Xuanxuan Ren Weiqing Zhang Hanqin Zhu Yu Wang Jiarou Qiu Fangying Wu Sisi Xu Zhaokai Jin Minchun Yang Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study BMC Cardiovascular Disorders Cross-sectional study Weight-adjusted-waist index Familial hypercholesterolaemia Obesity NHANES |
| title | Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study |
| title_full | Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study |
| title_fullStr | Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study |
| title_full_unstemmed | Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study |
| title_short | Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study |
| title_sort | association between the weight adjusted waist index and familial hypercholesterolemia a cross sectional study |
| topic | Cross-sectional study Weight-adjusted-waist index Familial hypercholesterolaemia Obesity NHANES |
| url | https://doi.org/10.1186/s12872-024-04293-0 |
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