Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study
Abstract Background Traditional treatment approaches for prescription-type opioid use disorder (POUD), centered on abstinence, have limitations and hinder the development of interventions that meet the needs of people with POUD. Reduction in use without complete abstinence presents a promising avenu...
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BMC
2025-02-01
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| Series: | Harm Reduction Journal |
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| Online Access: | https://doi.org/10.1186/s12954-025-01157-4 |
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| author | Anne Bouthillier Gabriel Bastien Christina McAnulty Hamzah Bakouni Bernard Le Foll M. Eugenia Socias Didier Jutras-Aswad |
| author_facet | Anne Bouthillier Gabriel Bastien Christina McAnulty Hamzah Bakouni Bernard Le Foll M. Eugenia Socias Didier Jutras-Aswad |
| author_sort | Anne Bouthillier |
| collection | DOAJ |
| description | Abstract Background Traditional treatment approaches for prescription-type opioid use disorder (POUD), centered on abstinence, have limitations and hinder the development of interventions that meet the needs of people with POUD. Reduction in use without complete abstinence presents a promising avenue for intervention enhancement, but supporting data is scarce regarding its translation into positive patient outcomes. This study explores whether reducing opioid use frequency (OUF) during opioid agonist treatment correlates with reduced potential life problems in individuals with POUD, including those using fentanyl. Methods This study is an exploratory analysis of the OPTIMA trial, a pragmatic, open-label, randomized controlled study comparing the effectiveness of flexible take-home dosing of buprenorphine/naloxone and supervised methadone in reducing opioid use amongst individuals with POUD. OUF was assessed every two weeks for 24 weeks after treatment initiation using the Timeline Followback. Potential life problems were evaluated at baseline and study completion using the Addiction Severity Index Self-Report. The 114 participants who completed both baseline and end-of-study questionnaires were included. A repeated-measures generalized linear mixed model (GLMM) was used to evaluate the influence of OUF on potential life problems. Results Reducing OUF was significantly associated with fewer problems related to medical status (p = 0.049), psychiatric status (p = 0.019), and alcohol problem severity (p = 0.001). The interaction was non-significant for employment (p = 0.264), family status (p = 0.352) and legal status (p = 0.050). Life improvements emerged with ≤ 21 days of opioid use per 28-day period. Conclusion Findings underscore the significance of harm reduction goals focusing on opioid use reduction, which translated in improvements across many life domains. Trial registration Study was registered with ClinicalTrials.gov (NCT03033732) prior to participant enrollment. |
| format | Article |
| id | doaj-art-127d9a0c312f4dc3a16c433ef1f7528a |
| institution | Kabale University |
| issn | 1477-7517 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Harm Reduction Journal |
| spelling | doaj-art-127d9a0c312f4dc3a16c433ef1f7528a2025-02-09T12:27:09ZengBMCHarm Reduction Journal1477-75172025-02-0122111310.1186/s12954-025-01157-4Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA StudyAnne Bouthillier0Gabriel Bastien1Christina McAnulty2Hamzah Bakouni3Bernard Le Foll4M. Eugenia Socias5Didier Jutras-Aswad6Department of Psychiatry and Addictology, Faculty of Medicine, Université de MontréalDepartment of Psychiatry and Addictology, Faculty of Medicine, Université de MontréalDepartment of Psychiatry and Addictology, Faculty of Medicine, Université de MontréalDepartment of Psychiatry and Addictology, Faculty of Medicine, Université de MontréalTranslational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Center for Addiction and Mental HealthBritish Columbia Centre on Substance UseDepartment of Psychiatry and Addictology, Faculty of Medicine, Université de MontréalAbstract Background Traditional treatment approaches for prescription-type opioid use disorder (POUD), centered on abstinence, have limitations and hinder the development of interventions that meet the needs of people with POUD. Reduction in use without complete abstinence presents a promising avenue for intervention enhancement, but supporting data is scarce regarding its translation into positive patient outcomes. This study explores whether reducing opioid use frequency (OUF) during opioid agonist treatment correlates with reduced potential life problems in individuals with POUD, including those using fentanyl. Methods This study is an exploratory analysis of the OPTIMA trial, a pragmatic, open-label, randomized controlled study comparing the effectiveness of flexible take-home dosing of buprenorphine/naloxone and supervised methadone in reducing opioid use amongst individuals with POUD. OUF was assessed every two weeks for 24 weeks after treatment initiation using the Timeline Followback. Potential life problems were evaluated at baseline and study completion using the Addiction Severity Index Self-Report. The 114 participants who completed both baseline and end-of-study questionnaires were included. A repeated-measures generalized linear mixed model (GLMM) was used to evaluate the influence of OUF on potential life problems. Results Reducing OUF was significantly associated with fewer problems related to medical status (p = 0.049), psychiatric status (p = 0.019), and alcohol problem severity (p = 0.001). The interaction was non-significant for employment (p = 0.264), family status (p = 0.352) and legal status (p = 0.050). Life improvements emerged with ≤ 21 days of opioid use per 28-day period. Conclusion Findings underscore the significance of harm reduction goals focusing on opioid use reduction, which translated in improvements across many life domains. Trial registration Study was registered with ClinicalTrials.gov (NCT03033732) prior to participant enrollment.https://doi.org/10.1186/s12954-025-01157-4Opioid use disorderHarm reductionPotential life problemsOpioid agonist treatmentPatient-centered outcomesOpioid use frequency |
| spellingShingle | Anne Bouthillier Gabriel Bastien Christina McAnulty Hamzah Bakouni Bernard Le Foll M. Eugenia Socias Didier Jutras-Aswad Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study Harm Reduction Journal Opioid use disorder Harm reduction Potential life problems Opioid agonist treatment Patient-centered outcomes Opioid use frequency |
| title | Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study |
| title_full | Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study |
| title_fullStr | Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study |
| title_full_unstemmed | Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study |
| title_short | Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study |
| title_sort | opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription type opioid use disorder exploratory results from the optima study |
| topic | Opioid use disorder Harm reduction Potential life problems Opioid agonist treatment Patient-centered outcomes Opioid use frequency |
| url | https://doi.org/10.1186/s12954-025-01157-4 |
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