Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

Abstract Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder. Through fluorescence‐activated nuclear suspension i...

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Bibliographic Details
Main Authors: Rafael Alcalá‐Vida, Marta Garcia‐Forn, Carla Castany‐Pladevall, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí‐Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro
Format: Article
Language:English
Published: Springer Nature 2020-12-01
Series:EMBO Molecular Medicine
Subjects:
chromatin accessibility
LAD
nuclear morphology
nuclear permeability
R6/1 mouse
Online Access:https://doi.org/10.15252/emmm.202012105
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