Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway
This study investigates the protective effect of ginsenoside Rg1 against manganese (Mn)-induced hepatotoxicity, highlighting its role as a PPAR-γ activator and its impact on TLR4/MyD88/MAPK pathway. Manganese induces liver damage through mechanisms involving oxidative stress and inflammation. Rg1, a...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132401649X |
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| author | Mengjing Zhao Min Zhang Shoudong Ni |
| author_facet | Mengjing Zhao Min Zhang Shoudong Ni |
| author_sort | Mengjing Zhao |
| collection | DOAJ |
| description | This study investigates the protective effect of ginsenoside Rg1 against manganese (Mn)-induced hepatotoxicity, highlighting its role as a PPAR-γ activator and its impact on TLR4/MyD88/MAPK pathway. Manganese induces liver damage through mechanisms involving oxidative stress and inflammation. Rg1, a principal bioactive compound of ginseng, significantly alleviates Mn-induced liver injury. Rg1 markedly enhances the activities of SOD, GSH, and CAT, while reducing levels of MDA and ROS, indicating an improvement in antioxidant defense capacity. Furthermore, Rg1 decreases inflammatory markers iNOS, TNF-α, IL-6, IL-12 and NO levels, underscoring its strong anti-inflammatory effects. Importantly, as a PPAR-γ activator, Rg1 upregulates PPAR-γ expression, subsequently inhibiting TLR4/MyD88/MAPK pathway. Additionally, silencing of PPAR-γ diminishes the protective effects of Rg1, while overexpression of PPAR-γ enhances them. The findings conclude that Rg1 exerts significant hepatoprotective effects against manganese-induced damage by activating PPAR-γ and modulating TLR4/MyD88/MAPK pathway, positioning it as a promising candidate for the treatment of Mn-induced hepatotoxicity. |
| format | Article |
| id | doaj-art-12799ac8624b4151b97c2febe8a9d312 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-12799ac8624b4151b97c2febe8a9d3122025-02-12T05:29:51ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117573Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathwayMengjing Zhao0Min Zhang1Shoudong Ni2Department of Pharmacy, Chaohu Hospital of Anhui Medical University, ChinaDepartment of Physical examination Center, Tongji Hospital Branch Affiliated to Tongji University, ChinaDepartment of Pharmacy, Chaohu Hospital of Anhui Medical University, China; Corresponding author.This study investigates the protective effect of ginsenoside Rg1 against manganese (Mn)-induced hepatotoxicity, highlighting its role as a PPAR-γ activator and its impact on TLR4/MyD88/MAPK pathway. Manganese induces liver damage through mechanisms involving oxidative stress and inflammation. Rg1, a principal bioactive compound of ginseng, significantly alleviates Mn-induced liver injury. Rg1 markedly enhances the activities of SOD, GSH, and CAT, while reducing levels of MDA and ROS, indicating an improvement in antioxidant defense capacity. Furthermore, Rg1 decreases inflammatory markers iNOS, TNF-α, IL-6, IL-12 and NO levels, underscoring its strong anti-inflammatory effects. Importantly, as a PPAR-γ activator, Rg1 upregulates PPAR-γ expression, subsequently inhibiting TLR4/MyD88/MAPK pathway. Additionally, silencing of PPAR-γ diminishes the protective effects of Rg1, while overexpression of PPAR-γ enhances them. The findings conclude that Rg1 exerts significant hepatoprotective effects against manganese-induced damage by activating PPAR-γ and modulating TLR4/MyD88/MAPK pathway, positioning it as a promising candidate for the treatment of Mn-induced hepatotoxicity.http://www.sciencedirect.com/science/article/pii/S014765132401649XGinsenoside Rg1ManganesePPAR-γLiver damageTLR4/MyD88/MAPK pathway |
| spellingShingle | Mengjing Zhao Min Zhang Shoudong Ni Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway Ecotoxicology and Environmental Safety Ginsenoside Rg1 Manganese PPAR-γ Liver damage TLR4/MyD88/MAPK pathway |
| title | Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway |
| title_full | Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway |
| title_fullStr | Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway |
| title_full_unstemmed | Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway |
| title_short | Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway |
| title_sort | role of ginsenoside rg1 as a ppar γ activator in protecting against manganese induced hepatotoxicity insights into the tlr4 myd88 mapk signaling pathway |
| topic | Ginsenoside Rg1 Manganese PPAR-γ Liver damage TLR4/MyD88/MAPK pathway |
| url | http://www.sciencedirect.com/science/article/pii/S014765132401649X |
| work_keys_str_mv | AT mengjingzhao roleofginsenosiderg1asappargactivatorinprotectingagainstmanganeseinducedhepatotoxicityinsightsintothetlr4myd88mapksignalingpathway AT minzhang roleofginsenosiderg1asappargactivatorinprotectingagainstmanganeseinducedhepatotoxicityinsightsintothetlr4myd88mapksignalingpathway AT shoudongni roleofginsenosiderg1asappargactivatorinprotectingagainstmanganeseinducedhepatotoxicityinsightsintothetlr4myd88mapksignalingpathway |