Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography
AIM: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiog...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-08-01
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| author | Yan-Mei Shi Xiao Xie Wen-Qi Wang Xiao-Meng Yuan Zhi-Ping Zhang Hong-Yan Wang Jie Meng Ze-Hao Kong Xia Jing Ting-Ting Liu |
| author_facet | Yan-Mei Shi Xiao Xie Wen-Qi Wang Xiao-Meng Yuan Zhi-Ping Zhang Hong-Yan Wang Jie Meng Ze-Hao Kong Xia Jing Ting-Ting Liu |
| author_sort | Yan-Mei Shi |
| collection | DOAJ |
| description | AIM: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques. METHODS: In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. A comprehensive panel of OCT and OCTA metrics was evaluated, including CMT, MNV area, VT, and VDisp. All subjects underwent a standardized intravitreal conbercept (IVC) regimen [3+pro re nata (PRN)] with a 12-month follow-up. MNV area was obtained by manual measurements with OCTA software, and VT and VDisp were calculated by automated analysis with Image J software. RESULTS: A total of 101 participants were included, with 51 patients in the type 1 MNV group (mean age 67.32±9.12y) and 50 patients in the type 2 MNV group (mean age 64.74±5.21y). The mean number of IVC injections was 3.98±1.53 for type 1 MNV and 3.73±0.81 for type 2 MNV. Both subtypes exhibited significant improvements in visual acuity, accompanied by marked reductions in CMT and MNV area (P<0.05) at 12mo after treatment. In type 2 MNV, VT significantly decreased (P<0.05), whereas no significant change was observed in VT for type 1 MNV. VDisp did not significantly changed in either sybtypes. Moreover, in type 1 MNV, final best-corrected visual acuity (BCVA) using logMAR correlated positively with both pre- and post-treatment CMT, while in type 2 MNV, a significant positive correlation was found between the number of injections and final CMT. CONCLUSION: This study shows that conbercept treatment significantly improves visual acuity and macular structure in both type 1 and type 2 MNV with reductions in CMT and MNV area. The significant reduction in VT in type 2 MNV suggests its potential as a biomarker for disease activity. The findings imply the quantitative assessment useful for the stratification, prognostication, and personalized management of MNV in nAMD. |
| format | Article |
| id | doaj-art-12791cffb14b4f33bc358fa755aa1db8 |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-12791cffb14b4f33bc358fa755aa1db82025-08-20T03:51:09ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-08-011881490149710.18240/ijo.2025.08.1020250810Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiographyYan-Mei Shi0Xiao Xie1Wen-Qi Wang2Xiao-Meng Yuan3Zhi-Ping Zhang4Hong-Yan Wang5Jie Meng6Ze-Hao Kong7Xia Jing8Ting-Ting Liu9Xia Jing. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China. Jingxia1027@163.com; Ting-Ting Liu. School of Ophthalmology, Shandong First Medical University, Jinan 250062, Shandong Province, China. tingtingliu@vip.sina.comThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China; Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China; Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, China; The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital), Jinan 250014, Shandong Province, ChinaEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, China; State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Jinan 250002, Shandong Province, China; School of Ophthalmology, Shandong First Medical University, Jinan 250062, Shandong Province, China; Tianjin Public Security Hospital, Tianjin 300042, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China; Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, ChinaEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, ChinaEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, ChinaDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, ChinaEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250002, Shandong Province, China; The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital), Jinan 250014, Shandong Province, China; State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Jinan 250002, Shandong Province, China; School of Ophthalmology, Shandong First Medical University, Jinan 250062, Shandong Province, ChinaAIM: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques. METHODS: In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. A comprehensive panel of OCT and OCTA metrics was evaluated, including CMT, MNV area, VT, and VDisp. All subjects underwent a standardized intravitreal conbercept (IVC) regimen [3+pro re nata (PRN)] with a 12-month follow-up. MNV area was obtained by manual measurements with OCTA software, and VT and VDisp were calculated by automated analysis with Image J software. RESULTS: A total of 101 participants were included, with 51 patients in the type 1 MNV group (mean age 67.32±9.12y) and 50 patients in the type 2 MNV group (mean age 64.74±5.21y). The mean number of IVC injections was 3.98±1.53 for type 1 MNV and 3.73±0.81 for type 2 MNV. Both subtypes exhibited significant improvements in visual acuity, accompanied by marked reductions in CMT and MNV area (P<0.05) at 12mo after treatment. In type 2 MNV, VT significantly decreased (P<0.05), whereas no significant change was observed in VT for type 1 MNV. VDisp did not significantly changed in either sybtypes. Moreover, in type 1 MNV, final best-corrected visual acuity (BCVA) using logMAR correlated positively with both pre- and post-treatment CMT, while in type 2 MNV, a significant positive correlation was found between the number of injections and final CMT. CONCLUSION: This study shows that conbercept treatment significantly improves visual acuity and macular structure in both type 1 and type 2 MNV with reductions in CMT and MNV area. The significant reduction in VT in type 2 MNV suggests its potential as a biomarker for disease activity. The findings imply the quantitative assessment useful for the stratification, prognostication, and personalized management of MNV in nAMD.http://ies.ijo.cn/en_publish/2025/8/20250810.pdfmacular neovascularizationage-related macular degenerationoptical coherence tomography angiographyconberceptvessel tortuosityvessel dispersion |
| spellingShingle | Yan-Mei Shi Xiao Xie Wen-Qi Wang Xiao-Meng Yuan Zhi-Ping Zhang Hong-Yan Wang Jie Meng Ze-Hao Kong Xia Jing Ting-Ting Liu Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography International Journal of Ophthalmology macular neovascularization age-related macular degeneration optical coherence tomography angiography conbercept vessel tortuosity vessel dispersion |
| title | Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography |
| title_full | Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography |
| title_fullStr | Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography |
| title_full_unstemmed | Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography |
| title_short | Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography |
| title_sort | quantitative characterization of types 1 and 2 macular neovascularization in neovascular age related macular degeneration with intravitreal conbercept an analysis utilizing optical coherence tomography angiography |
| topic | macular neovascularization age-related macular degeneration optical coherence tomography angiography conbercept vessel tortuosity vessel dispersion |
| url | http://ies.ijo.cn/en_publish/2025/8/20250810.pdf |
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