Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury
Abstract Sepsis is a syndrome of organ dysfunction caused by the invasion of pathogenic microorganisms. In clinical practice, patients with sepsis are prone to concurrent acute kidney injury, which has high morbidity and mortality rates. Thus, understanding the pathogenesis of sepsis-associated acut...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13148-025-01861-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726735396896768 |
|---|---|
| author | Yuhang Yang Xinqi Deng Wenyuan Li Yan Leng Yonghong Xiong Bihan Wang Siyuan Gong Yunhao Wang Baichuan Yang Wei Li |
| author_facet | Yuhang Yang Xinqi Deng Wenyuan Li Yan Leng Yonghong Xiong Bihan Wang Siyuan Gong Yunhao Wang Baichuan Yang Wei Li |
| author_sort | Yuhang Yang |
| collection | DOAJ |
| description | Abstract Sepsis is a syndrome of organ dysfunction caused by the invasion of pathogenic microorganisms. In clinical practice, patients with sepsis are prone to concurrent acute kidney injury, which has high morbidity and mortality rates. Thus, understanding the pathogenesis of sepsis-associated acute kidney injury is of significant clinical importance. Ferroptosis is an iron-dependent programmed cell death pathway, which is proved to play a critical role in the process of sepsis-associated acute kidney injury through various mechanisms. Epigenetic regulation modulates the content and function of nucleic acids and proteins within cells through various modifications. Its impact on ferroptosis has garnered increasing attention; however, the role of epigenetic regulation targeting ferroptosis in sepsis-associated acute kidney injury has not been fully elucidated. Growing evidence suggests that epigenetic regulation can modulate ferroptosis through complex pathway networks, thereby affecting the development and prognosis of sepsis-associated acute kidney injury. This paper summarizes the impact of ferroptosis on sepsis-associated acute kidney injury and the regulatory mechanisms of epigenetic regulation on ferroptosis, providing new insights for the targeted therapy of sepsis-associated acute kidney injury. |
| format | Article |
| id | doaj-art-1278c8fefad34bf28d96c65cbde8f98c |
| institution | DOAJ |
| issn | 1868-7083 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-1278c8fefad34bf28d96c65cbde8f98c2025-08-20T03:10:06ZengBMCClinical Epigenetics1868-70832025-04-0117111410.1186/s13148-025-01861-9Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injuryYuhang Yang0Xinqi Deng1Wenyuan Li2Yan Leng3Yonghong Xiong4Bihan Wang5Siyuan Gong6Yunhao Wang7Baichuan Yang8Wei Li9Department of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityDepartment of Anesthesiology, Renmin Hospital of Wuhan UniversityAbstract Sepsis is a syndrome of organ dysfunction caused by the invasion of pathogenic microorganisms. In clinical practice, patients with sepsis are prone to concurrent acute kidney injury, which has high morbidity and mortality rates. Thus, understanding the pathogenesis of sepsis-associated acute kidney injury is of significant clinical importance. Ferroptosis is an iron-dependent programmed cell death pathway, which is proved to play a critical role in the process of sepsis-associated acute kidney injury through various mechanisms. Epigenetic regulation modulates the content and function of nucleic acids and proteins within cells through various modifications. Its impact on ferroptosis has garnered increasing attention; however, the role of epigenetic regulation targeting ferroptosis in sepsis-associated acute kidney injury has not been fully elucidated. Growing evidence suggests that epigenetic regulation can modulate ferroptosis through complex pathway networks, thereby affecting the development and prognosis of sepsis-associated acute kidney injury. This paper summarizes the impact of ferroptosis on sepsis-associated acute kidney injury and the regulatory mechanisms of epigenetic regulation on ferroptosis, providing new insights for the targeted therapy of sepsis-associated acute kidney injury.https://doi.org/10.1186/s13148-025-01861-9Acute kidney injurySepsisFerroptosisEpigenetic regulation |
| spellingShingle | Yuhang Yang Xinqi Deng Wenyuan Li Yan Leng Yonghong Xiong Bihan Wang Siyuan Gong Yunhao Wang Baichuan Yang Wei Li Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury Clinical Epigenetics Acute kidney injury Sepsis Ferroptosis Epigenetic regulation |
| title | Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury |
| title_full | Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury |
| title_fullStr | Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury |
| title_full_unstemmed | Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury |
| title_short | Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury |
| title_sort | targeting the epigenetic regulation of ferroptosis a potential therapeutic approach for sepsis associated acute kidney injury |
| topic | Acute kidney injury Sepsis Ferroptosis Epigenetic regulation |
| url | https://doi.org/10.1186/s13148-025-01861-9 |
| work_keys_str_mv | AT yuhangyang targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT xinqideng targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT wenyuanli targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT yanleng targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT yonghongxiong targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT bihanwang targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT siyuangong targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT yunhaowang targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT baichuanyang targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury AT weili targetingtheepigeneticregulationofferroptosisapotentialtherapeuticapproachforsepsisassociatedacutekidneyinjury |