The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma
Long noncoding RNAs play an important role in various biological processes, including tumorigenesis. FOXC1 (Forkhead box C1) is a member of the Forkhead box family of transcription factors and plays a crucial role in nasopharyngeal carcinoma. In this study, a novel long noncoding RNA (FOXCUT) locate...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-06-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317706054 |
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| author | Yu-zhong Xu Fang-fang Chen Yu Zhang Qin-fei Zhao Xiao-long Guan Hai-yong Wang Ang Li Xin Lv Shu-sheng Song Ying Zhou Xiao-jun Li |
| author_facet | Yu-zhong Xu Fang-fang Chen Yu Zhang Qin-fei Zhao Xiao-long Guan Hai-yong Wang Ang Li Xin Lv Shu-sheng Song Ying Zhou Xiao-jun Li |
| author_sort | Yu-zhong Xu |
| collection | DOAJ |
| description | Long noncoding RNAs play an important role in various biological processes, including tumorigenesis. FOXC1 (Forkhead box C1) is a member of the Forkhead box family of transcription factors and plays a crucial role in nasopharyngeal carcinoma. In this study, a novel long noncoding RNA (FOXCUT) located upstream of FOXC1 was investigated in 42 nasopharyngeal carcinoma patients. Our analysis revealed that the expression levels of FOXCUT and FOXC1 in nasopharyngeal carcinoma tissues were significantly higher than those observed in chronic nasopharyngitis tissues and that FOXCUT expression was positively correlated with FOXC1 expression. Additionally, knockdown of FOXCUT significantly inhibited proliferation and migration of nasopharyngeal carcinoma cell lines and resulted in downregulated expression of the matrix metalloproteinase 7 and matrix metalloproteinase 9, as well as vascular endothelial growth factor A and β-catenin. Our findings suggested that FOXCUT expression contributed to the development and progression of nasopharyngeal carcinoma by targeting FOXC1 and that FOXCUT might be useful as a potential nasopharyngeal carcinoma biomarker and therapeutic target. |
| format | Article |
| id | doaj-art-12757b8200c34dc29cc54df7bd016afb |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-12757b8200c34dc29cc54df7bd016afb2025-08-20T03:32:47ZengSAGE PublishingTumor Biology1423-03802017-06-013910.1177/1010428317706054The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinomaYu-zhong Xu0Fang-fang Chen1Yu Zhang2Qin-fei Zhao3Xiao-long Guan4Hai-yong Wang5Ang Li6Xin Lv7Shu-sheng Song8Ying Zhou9Xiao-jun Li10Department of Clinical Laboratory, Shenzhen Bao’an Hospital, Southern Medical University, Shenzhen, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaInstitute of Clinical Laboratory Science, Jinling Hospital, Southern Medical University, Nanjing, ChinaLong noncoding RNAs play an important role in various biological processes, including tumorigenesis. FOXC1 (Forkhead box C1) is a member of the Forkhead box family of transcription factors and plays a crucial role in nasopharyngeal carcinoma. In this study, a novel long noncoding RNA (FOXCUT) located upstream of FOXC1 was investigated in 42 nasopharyngeal carcinoma patients. Our analysis revealed that the expression levels of FOXCUT and FOXC1 in nasopharyngeal carcinoma tissues were significantly higher than those observed in chronic nasopharyngitis tissues and that FOXCUT expression was positively correlated with FOXC1 expression. Additionally, knockdown of FOXCUT significantly inhibited proliferation and migration of nasopharyngeal carcinoma cell lines and resulted in downregulated expression of the matrix metalloproteinase 7 and matrix metalloproteinase 9, as well as vascular endothelial growth factor A and β-catenin. Our findings suggested that FOXCUT expression contributed to the development and progression of nasopharyngeal carcinoma by targeting FOXC1 and that FOXCUT might be useful as a potential nasopharyngeal carcinoma biomarker and therapeutic target.https://doi.org/10.1177/1010428317706054 |
| spellingShingle | Yu-zhong Xu Fang-fang Chen Yu Zhang Qin-fei Zhao Xiao-long Guan Hai-yong Wang Ang Li Xin Lv Shu-sheng Song Ying Zhou Xiao-jun Li The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma Tumor Biology |
| title | The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma |
| title_full | The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma |
| title_fullStr | The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma |
| title_full_unstemmed | The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma |
| title_short | The long noncoding RNA FOXCUT promotes proliferation and migration by targeting in nasopharyngeal carcinoma |
| title_sort | long noncoding rna foxcut promotes proliferation and migration by targeting in nasopharyngeal carcinoma |
| url | https://doi.org/10.1177/1010428317706054 |
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