The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study
Introduction: Diphtheria is a serious infectious disease although being vaccine-preventable. 5-year follow-up study aimed to evaluate the persistence of IgG antibodies to diphtheria toxoid after Tetanus-diphtheria primary immunization for persons aged 6-25 years in Kon Tum, Viet Nam. Methodology:...
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The Journal of Infection in Developing Countries
2025-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19390 |
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| author | Tuan Van Le Van Thi Tuyet Nguyen Quan Hoang Nguyen Huong Le Thien Tran Son Dinh Tran Chien Chinh Vien |
| author_facet | Tuan Van Le Van Thi Tuyet Nguyen Quan Hoang Nguyen Huong Le Thien Tran Son Dinh Tran Chien Chinh Vien |
| author_sort | Tuan Van Le |
| collection | DOAJ |
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Introduction: Diphtheria is a serious infectious disease although being vaccine-preventable. 5-year follow-up study aimed to evaluate the persistence of IgG antibodies to diphtheria toxoid after Tetanus-diphtheria primary immunization for persons aged 6-25 years in Kon Tum, Viet Nam.
Methodology: Blood samples were obtained from 128 healthy persons aged 6-25 years collected in 2021. Samples were tested for diphtheria toxoid antibodies by commercial Anti-Diphtheria Toxoid IgG Enzyme-Linked Immunosorbent Assay (ELISA).
Results: One month after Td primary vaccination, 92.2% of participants were fully protected against diphtheria (> 0.1 IU/mL). GMCs increased from 0.04 to 0.91 IU/mL at one month, which were maintained in nearly 90% of vaccinees at 5 years. Among children aged 6-10 years, 97.3% had full protection at 1 month after primary vaccination, maintained in 94.6% at 5 years. Among adolescents and adults, 81.0% to 98.5% had full protection at 1 month after vaccination, which were maintained from 72.7% to 96.7% at 5 years. Although, the antibodies slightly declined approximately 5 years post-vaccination, but remained several-fold higher than pre-vaccination.
Conclusions: Td vaccine provides long-lasting protective antibodies against diphtheria. These data may inform discussion of the need for Td booster vaccinations among high-risk persons.
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| format | Article |
| id | doaj-art-1270d8b4a7fb41caa5c6efc981a6f112 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-1270d8b4a7fb41caa5c6efc981a6f1122025-08-20T02:27:07ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-01-01190110.3855/jidc.19390The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up studyTuan Van Le0Van Thi Tuyet Nguyen1Quan Hoang Nguyen2Huong Le Thien Tran3Son Dinh Tran4Chien Chinh Vien5Department of Microbiology and Immunology, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, VietnamDepartment of Microbiology and Immunology, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, VietnamDepartment of Microbiology and Immunology, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, VietnamDepartment of Microbiology and Immunology, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, VietnamDepartment of Microbiology and Immunology, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, VietnamCommunicable Disease Control Department, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, Vietnam Introduction: Diphtheria is a serious infectious disease although being vaccine-preventable. 5-year follow-up study aimed to evaluate the persistence of IgG antibodies to diphtheria toxoid after Tetanus-diphtheria primary immunization for persons aged 6-25 years in Kon Tum, Viet Nam. Methodology: Blood samples were obtained from 128 healthy persons aged 6-25 years collected in 2021. Samples were tested for diphtheria toxoid antibodies by commercial Anti-Diphtheria Toxoid IgG Enzyme-Linked Immunosorbent Assay (ELISA). Results: One month after Td primary vaccination, 92.2% of participants were fully protected against diphtheria (> 0.1 IU/mL). GMCs increased from 0.04 to 0.91 IU/mL at one month, which were maintained in nearly 90% of vaccinees at 5 years. Among children aged 6-10 years, 97.3% had full protection at 1 month after primary vaccination, maintained in 94.6% at 5 years. Among adolescents and adults, 81.0% to 98.5% had full protection at 1 month after vaccination, which were maintained from 72.7% to 96.7% at 5 years. Although, the antibodies slightly declined approximately 5 years post-vaccination, but remained several-fold higher than pre-vaccination. Conclusions: Td vaccine provides long-lasting protective antibodies against diphtheria. These data may inform discussion of the need for Td booster vaccinations among high-risk persons. https://jidc.org/index.php/journal/article/view/19390Diphtheriatetanus-diphtheria vaccineantibodiesseroprevalenceKon TumVietnam |
| spellingShingle | Tuan Van Le Van Thi Tuyet Nguyen Quan Hoang Nguyen Huong Le Thien Tran Son Dinh Tran Chien Chinh Vien The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study Journal of Infection in Developing Countries Diphtheria tetanus-diphtheria vaccine antibodies seroprevalence Kon Tum Vietnam |
| title | The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study |
| title_full | The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study |
| title_fullStr | The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study |
| title_full_unstemmed | The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study |
| title_short | The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study |
| title_sort | evaluation of anti diphtheria toxoid antibodies after 5 years with the primary tetanus diphtheria vaccine in persons aged 6 25 years in kon tum vietnam a follow up study |
| topic | Diphtheria tetanus-diphtheria vaccine antibodies seroprevalence Kon Tum Vietnam |
| url | https://jidc.org/index.php/journal/article/view/19390 |
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