Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging
The highly sensitive detection and imaging of biomarkers are critical for early diagnosis, treatment, and prognosis monitoring. The unique size and structure of fluorescent nanomaterials provide key benefits such as excellent photostability, high fluorescence quantum yield, and tunable excitation an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425003230 |
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| author | Xuming Sun Tong Xiang Linyan Xie Qiongqiong Ren Jinlong Chang Wenshuai Jiang Zhen Jin Xiuli Yang Wu Ren Yi Yu |
| author_facet | Xuming Sun Tong Xiang Linyan Xie Qiongqiong Ren Jinlong Chang Wenshuai Jiang Zhen Jin Xiuli Yang Wu Ren Yi Yu |
| author_sort | Xuming Sun |
| collection | DOAJ |
| description | The highly sensitive detection and imaging of biomarkers are critical for early diagnosis, treatment, and prognosis monitoring. The unique size and structure of fluorescent nanomaterials provide key benefits such as excellent photostability, high fluorescence quantum yield, and tunable excitation and emission wavelengths. These properties have led to the widespread application of nanomaterials in fluorescent biomarkers detection and imaging. In this review, we began by introducing the composition of fluorescent probes and discussing the underlying sensing mechanisms. We then summarized recent advances in the use of fluorescent nanomaterials such as quantum dots (QDs), metal nanoclusters (MNCs), carbon dots (CDs), and metal-organic frameworks (MOFs) for biomarker detection and imaging. Additionally, we highlighted the applications of fluorescent nanomaterials in the detection and imaging of small molecules, biomacromolecules, and various biomarkers, including metal ions, bacteria, and circulating tumor cells (CTCs). The challenges and future prospects of fluorescent nanomaterials in biomarker detection and imaging were also discussed. We anticipate that fluorescent nanomaterials will have profound implications for clinical biomarker detection and imaging, with considerable application in both academic research and industrial applications. |
| format | Article |
| id | doaj-art-12702b796889483ebe71e052d38556f3 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-12702b796889483ebe71e052d38556f32025-08-20T02:12:07ZengElsevierMaterials Today Bio2590-00642025-06-013210176310.1016/j.mtbio.2025.101763Recent advances in fluorescent nanomaterials designed for biomarker detection and imagingXuming Sun0Tong Xiang1Linyan Xie2Qiongqiong Ren3Jinlong Chang4Wenshuai Jiang5Zhen Jin6Xiuli Yang7Wu Ren8Yi Yu9School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang, 453003, PR China; Corresponding author. School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China.School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang, 453003, PR ChinaSchool of Mathematical Medicine, Xinxiang Medical University, Xinxiang, 453003, PR China; Corresponding author.School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang, 453003, PR ChinaSchool of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR ChinaSchool of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang, 453003, PR ChinaSchool of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang, 453003, PR ChinaDepartment of Cardiology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, PR ChinaSchool of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Corresponding author.School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, PR China; Corresponding author.The highly sensitive detection and imaging of biomarkers are critical for early diagnosis, treatment, and prognosis monitoring. The unique size and structure of fluorescent nanomaterials provide key benefits such as excellent photostability, high fluorescence quantum yield, and tunable excitation and emission wavelengths. These properties have led to the widespread application of nanomaterials in fluorescent biomarkers detection and imaging. In this review, we began by introducing the composition of fluorescent probes and discussing the underlying sensing mechanisms. We then summarized recent advances in the use of fluorescent nanomaterials such as quantum dots (QDs), metal nanoclusters (MNCs), carbon dots (CDs), and metal-organic frameworks (MOFs) for biomarker detection and imaging. Additionally, we highlighted the applications of fluorescent nanomaterials in the detection and imaging of small molecules, biomacromolecules, and various biomarkers, including metal ions, bacteria, and circulating tumor cells (CTCs). The challenges and future prospects of fluorescent nanomaterials in biomarker detection and imaging were also discussed. We anticipate that fluorescent nanomaterials will have profound implications for clinical biomarker detection and imaging, with considerable application in both academic research and industrial applications.http://www.sciencedirect.com/science/article/pii/S2590006425003230BiomarkerFluorescenceNanomaterialsImaging |
| spellingShingle | Xuming Sun Tong Xiang Linyan Xie Qiongqiong Ren Jinlong Chang Wenshuai Jiang Zhen Jin Xiuli Yang Wu Ren Yi Yu Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging Materials Today Bio Biomarker Fluorescence Nanomaterials Imaging |
| title | Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging |
| title_full | Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging |
| title_fullStr | Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging |
| title_full_unstemmed | Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging |
| title_short | Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging |
| title_sort | recent advances in fluorescent nanomaterials designed for biomarker detection and imaging |
| topic | Biomarker Fluorescence Nanomaterials Imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425003230 |
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