Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand–Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Keratinocyte Toxicity

Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand–Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Keratinocyte Toxicity

In recent years, molecular target drugs have become integral in treating malignant tumours. Multikinase inhibitors (MKIs) have been associated with serious skin disorders, including hand–foot skin reaction (HFSR), which impair patient quality of life, often disrupting activities of daily living nece...

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Bibliographic Details
Main Authors: Rui Kato, Yayoi Kamata, Mitsutoshi Tominaga, Ryoma Kishi, Takahide Kaneko, Akira Tsujimura, Yasushi Suga, Kenji Takamori
Format: Article
Language:English
Published: Medical Journals Sweden 2025-04-01
Series:Acta Dermato-Venereologica
Subjects:
Multikinase inhibitor
Sorafenib
Antifungal drug
Ketoconazole
Itraconazole
Online Access:https://medicaljournalssweden.se/actadv/article/view/40697
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