Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria
Study’s Excerpt • The utilization of haematological parameters as supplementary markers for monitoring HIV treatment and disease progression is assessed. • The relationships between haematological indices and both CD4+ cell counts and viral loads is analyzed. • These parameters could serve as a...
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| Format: | Article |
| Language: | English |
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Umaru Musa Yar'adua University, Katsina, Nigeria
2024-12-01
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| Series: | UMYU Journal of Microbiology Research |
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| Online Access: | https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/635 |
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| author | Rahamat I Ishaq Aliyu Dutsinma Usman M Bashir |
| author_facet | Rahamat I Ishaq Aliyu Dutsinma Usman M Bashir |
| author_sort | Rahamat I Ishaq |
| collection | DOAJ |
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Study’s Excerpt
• The utilization of haematological parameters as supplementary markers for monitoring HIV treatment and disease progression is assessed.
• The relationships between haematological indices and both CD4+ cell counts and viral loads is analyzed.
• These parameters could serve as alternative monitoring approaches in tracking HIV status.
Full Abstract
The cluster of differentiation-4 (CD4+) cell counts and HIV RNA concentration are the biomarkers used in treatment monitoring and HIV disease progression. However, this presents unique challenges in resource-limited settings due to limited healthcare infrastructure, financial constraints, and reduced access to diagnostic tools. This study aims to evaluate and compare the haematological parameters of HIV-positive patients and compare them with their CD4+ cell and viral load counts to ascertain their usefulness in monitoring HIV treatment and disease progression. One hundred and ninety-six (196) HIV-positive clients already on antiretroviral therapy, aged 18-75 years old, were enrolled, and their haematological parameters, Viral load, and CD4+ cell counts were evaluated. The data obtained were analyzed using descriptive statistics, one-way ANOVA, and Tukey's multiple comparison analysis. The mean (±SD) age of the study participants was 39.42 ±3.78 years. A comparison of the haematological indices of study participants based on their CD4+ cell counts reveals a significant difference between the mean of participants in stages I and II of HIV disease progression (P-value: 0.023). Also, the mean lymphocyte counts for participants in stages I and II and between those in stages II and III were significantly different (P-value: 0.0017, <0.0001, respectively). However, when participants were grouped based on their Viral load count, a significant difference was only observed for white blood cell (WBC) count between those whose viral load was below 20 copies/ml and those with above 1000 copies/ml (P-value 0.0421). Conclusively, it was observed that there is a relatively significant difference in WBC count, lymphocyte counts, and percentage lymphocyte count based on the participant's CD4+ cell and viral load count. Mild anaemia was also documented. These findings further substantiate the importance of haematological parameters in HIV treatment and disease progression monitoring.
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| format | Article |
| id | doaj-art-1256feda7a68414986344b979ebaf8b3 |
| institution | Kabale University |
| issn | 2616-0668 2814-1822 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Umaru Musa Yar'adua University, Katsina, Nigeria |
| record_format | Article |
| series | UMYU Journal of Microbiology Research |
| spelling | doaj-art-1256feda7a68414986344b979ebaf8b32025-01-08T12:02:04ZengUmaru Musa Yar'adua University, Katsina, NigeriaUMYU Journal of Microbiology Research2616-06682814-18222024-12-019210.47430/ujmr.2492.013Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, NigeriaRahamat I Ishaq0Aliyu Dutsinma Usman1M Bashir2Department of Biological Sciences, Yusuf Maitama Sule University, Kano, NigeriaDepartment of Microbiology, Bayero University Kano, NigeriaDepartment of Microbiology, Bayero University Kano, Nigeria Study’s Excerpt • The utilization of haematological parameters as supplementary markers for monitoring HIV treatment and disease progression is assessed. • The relationships between haematological indices and both CD4+ cell counts and viral loads is analyzed. • These parameters could serve as alternative monitoring approaches in tracking HIV status. Full Abstract The cluster of differentiation-4 (CD4+) cell counts and HIV RNA concentration are the biomarkers used in treatment monitoring and HIV disease progression. However, this presents unique challenges in resource-limited settings due to limited healthcare infrastructure, financial constraints, and reduced access to diagnostic tools. This study aims to evaluate and compare the haematological parameters of HIV-positive patients and compare them with their CD4+ cell and viral load counts to ascertain their usefulness in monitoring HIV treatment and disease progression. One hundred and ninety-six (196) HIV-positive clients already on antiretroviral therapy, aged 18-75 years old, were enrolled, and their haematological parameters, Viral load, and CD4+ cell counts were evaluated. The data obtained were analyzed using descriptive statistics, one-way ANOVA, and Tukey's multiple comparison analysis. The mean (±SD) age of the study participants was 39.42 ±3.78 years. A comparison of the haematological indices of study participants based on their CD4+ cell counts reveals a significant difference between the mean of participants in stages I and II of HIV disease progression (P-value: 0.023). Also, the mean lymphocyte counts for participants in stages I and II and between those in stages II and III were significantly different (P-value: 0.0017, <0.0001, respectively). However, when participants were grouped based on their Viral load count, a significant difference was only observed for white blood cell (WBC) count between those whose viral load was below 20 copies/ml and those with above 1000 copies/ml (P-value 0.0421). Conclusively, it was observed that there is a relatively significant difference in WBC count, lymphocyte counts, and percentage lymphocyte count based on the participant's CD4+ cell and viral load count. Mild anaemia was also documented. These findings further substantiate the importance of haematological parameters in HIV treatment and disease progression monitoring. https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/635HIVCD4 countsViral load countsHaematological profileWhite blood cell countsLymphocyte |
| spellingShingle | Rahamat I Ishaq Aliyu Dutsinma Usman M Bashir Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria UMYU Journal of Microbiology Research HIV CD4 counts Viral load counts Haematological profile White blood cell counts Lymphocyte |
| title | Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria |
| title_full | Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria |
| title_fullStr | Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria |
| title_full_unstemmed | Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria |
| title_short | Comparative Assessment of Haematological Profile, CD4 Cell and Viral Load Counts of HIV-Positive Clients Attending Aminu Kano Teaching Hospital (AKTH), Kano State, Nigeria |
| title_sort | comparative assessment of haematological profile cd4 cell and viral load counts of hiv positive clients attending aminu kano teaching hospital akth kano state nigeria |
| topic | HIV CD4 counts Viral load counts Haematological profile White blood cell counts Lymphocyte |
| url | https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/635 |
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