Immunoregulatory functions of immune complexes in vaccine and therapy
Abstract Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vac...
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| Format: | Article |
| Language: | English |
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Springer Nature
2016-08-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201606593 |
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| author | Yu‐mei Wen Libing Mu Yan Shi |
| author_facet | Yu‐mei Wen Libing Mu Yan Shi |
| author_sort | Yu‐mei Wen |
| collection | DOAJ |
| description | Abstract Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vaccination, for at least a century. With intensified research on Fcγ receptor‐mediated immune modulation, as well as with immune complex‐directed antigen processing, presentation, and inflammatory responses, there are renewed interests of using ICs in vaccines and immunotherapies. Currently, IC‐based immune therapy has been broadly experimented in HBV and HIV viral infection control and antitumor treatments. However, mechanistic insights of IC‐based treatments are relatively recent subjects of study; strong efforts are needed to establish links to connect laboratory findings with clinical practices. This review covers the history, mechanisms, and in vivo outcomes of this safe and effective therapeutic tool, with a clear aim to bridge laboratory findings with evolving clinical applications. |
| format | Article |
| id | doaj-art-1256d4a5a3de4f8ebf8fe6913c67cb89 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-1256d4a5a3de4f8ebf8fe6913c67cb892025-08-20T03:46:24ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-08-018101120113310.15252/emmm.201606593Immunoregulatory functions of immune complexes in vaccine and therapyYu‐mei Wen0Libing Mu1Yan Shi2Key Laboratory of Molecular Medical Virology, MOE/MOH, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityCenter for Life Sciences, Department of Basic Medical Sciences, Institute of Immunology Tsinghua UniversityCenter for Life Sciences, Department of Basic Medical Sciences, Institute of Immunology Tsinghua UniversityAbstract Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vaccination, for at least a century. With intensified research on Fcγ receptor‐mediated immune modulation, as well as with immune complex‐directed antigen processing, presentation, and inflammatory responses, there are renewed interests of using ICs in vaccines and immunotherapies. Currently, IC‐based immune therapy has been broadly experimented in HBV and HIV viral infection control and antitumor treatments. However, mechanistic insights of IC‐based treatments are relatively recent subjects of study; strong efforts are needed to establish links to connect laboratory findings with clinical practices. This review covers the history, mechanisms, and in vivo outcomes of this safe and effective therapeutic tool, with a clear aim to bridge laboratory findings with evolving clinical applications.https://doi.org/10.15252/emmm.201606593adjuvantFcγRimmune compleximmune therapyvaccine |
| spellingShingle | Yu‐mei Wen Libing Mu Yan Shi Immunoregulatory functions of immune complexes in vaccine and therapy EMBO Molecular Medicine adjuvant FcγR immune complex immune therapy vaccine |
| title | Immunoregulatory functions of immune complexes in vaccine and therapy |
| title_full | Immunoregulatory functions of immune complexes in vaccine and therapy |
| title_fullStr | Immunoregulatory functions of immune complexes in vaccine and therapy |
| title_full_unstemmed | Immunoregulatory functions of immune complexes in vaccine and therapy |
| title_short | Immunoregulatory functions of immune complexes in vaccine and therapy |
| title_sort | immunoregulatory functions of immune complexes in vaccine and therapy |
| topic | adjuvant FcγR immune complex immune therapy vaccine |
| url | https://doi.org/10.15252/emmm.201606593 |
| work_keys_str_mv | AT yumeiwen immunoregulatoryfunctionsofimmunecomplexesinvaccineandtherapy AT libingmu immunoregulatoryfunctionsofimmunecomplexesinvaccineandtherapy AT yanshi immunoregulatoryfunctionsofimmunecomplexesinvaccineandtherapy |