Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report
Over the past decade, immune checkpoint inhibitors (ICIs) have emerged as a crucial therapeutic option for treating various malignancies. Nivolumab, an ICI, is a monoclonal antibody directed against programmed cell death protein 1. However, many studies indicate that ICIs can lead to various immune-...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Acta Neurologica Taiwanica |
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| Online Access: | https://journals.lww.com/10.4103/ANT.ANT_112_0090 |
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| author | Bo-Kang Cheng Chien-An Ko Chun-Lin Kuo Te-Chi Nai Wei Lin Chung-Hsing Chou Yueh-Feng Sung |
| author_facet | Bo-Kang Cheng Chien-An Ko Chun-Lin Kuo Te-Chi Nai Wei Lin Chung-Hsing Chou Yueh-Feng Sung |
| author_sort | Bo-Kang Cheng |
| collection | DOAJ |
| description | Over the past decade, immune checkpoint inhibitors (ICIs) have emerged as a crucial therapeutic option for treating various malignancies. Nivolumab, an ICI, is a monoclonal antibody directed against programmed cell death protein 1. However, many studies indicate that ICIs can lead to various immune-related adverse events (irAEs), with neurological irAEs accounting for approximately 1%–5% of these cases. Neurological adverse events such as Guillain–Barre syndrome (GBS) are rare but life threatening. This report presents the case of a 72-year-old male diagnosed with sarcomatoid squamous cell carcinoma of the trachea, who was admitted with rapid-onset weakness of the upper limbs 7 days following the latest nivolumab treatment. These symptoms progressed quickly to quadriplegia and respiratory failure, requiring intubation and mechanical ventilation. Serum antiganglioside antibodies were positive for immunoglobulin (Ig) M-GM1, IgM-GD1b, and IgG-GM3. His clinical symptoms improved significantly after steroid and intravenous immunoglobulin treatment. This rare and atypical case highlights the complexity of ICI-related GBS. Early recognition of associated symptoms is crucial for timely and appropriate treatment. |
| format | Article |
| id | doaj-art-1256080746d84c6788eaef66d5596b00 |
| institution | Kabale University |
| issn | 1028-768X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Neurologica Taiwanica |
| spelling | doaj-art-1256080746d84c6788eaef66d5596b002025-08-20T03:24:43ZengWolters Kluwer Medknow PublicationsActa Neurologica Taiwanica1028-768X2025-01-01341353910.4103/ANT.ANT_112_0090Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case ReportBo-Kang ChengChien-An KoChun-Lin KuoTe-Chi NaiWei LinChung-Hsing ChouYueh-Feng SungOver the past decade, immune checkpoint inhibitors (ICIs) have emerged as a crucial therapeutic option for treating various malignancies. Nivolumab, an ICI, is a monoclonal antibody directed against programmed cell death protein 1. However, many studies indicate that ICIs can lead to various immune-related adverse events (irAEs), with neurological irAEs accounting for approximately 1%–5% of these cases. Neurological adverse events such as Guillain–Barre syndrome (GBS) are rare but life threatening. This report presents the case of a 72-year-old male diagnosed with sarcomatoid squamous cell carcinoma of the trachea, who was admitted with rapid-onset weakness of the upper limbs 7 days following the latest nivolumab treatment. These symptoms progressed quickly to quadriplegia and respiratory failure, requiring intubation and mechanical ventilation. Serum antiganglioside antibodies were positive for immunoglobulin (Ig) M-GM1, IgM-GD1b, and IgG-GM3. His clinical symptoms improved significantly after steroid and intravenous immunoglobulin treatment. This rare and atypical case highlights the complexity of ICI-related GBS. Early recognition of associated symptoms is crucial for timely and appropriate treatment.https://journals.lww.com/10.4103/ANT.ANT_112_0090antiganglioside antibodiescase reportguillain–barre syndromeimmune checkpoint inhibitorimmune-related adverse eventsintravenous immunoglobulinnivolumab |
| spellingShingle | Bo-Kang Cheng Chien-An Ko Chun-Lin Kuo Te-Chi Nai Wei Lin Chung-Hsing Chou Yueh-Feng Sung Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report Acta Neurologica Taiwanica antiganglioside antibodies case report guillain–barre syndrome immune checkpoint inhibitor immune-related adverse events intravenous immunoglobulin nivolumab |
| title | Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report |
| title_full | Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report |
| title_fullStr | Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report |
| title_full_unstemmed | Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report |
| title_short | Guillain–Barre Syndrome-Like Polyneuropathy Induced by Immune Checkpoint Inhibitors: A Case Report |
| title_sort | guillain barre syndrome like polyneuropathy induced by immune checkpoint inhibitors a case report |
| topic | antiganglioside antibodies case report guillain–barre syndrome immune checkpoint inhibitor immune-related adverse events intravenous immunoglobulin nivolumab |
| url | https://journals.lww.com/10.4103/ANT.ANT_112_0090 |
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