Discovery of homocamptothecin derivative TOP-0618 as a radiosensitive agent for the treatment of pancreatic cancer

Discovery of homocamptothecin derivative TOP-0618 as a radiosensitive agent for the treatment of pancreatic cancer

Abstract Background Pancreatic cancer is one of the most lethal malignancies characterized by a complex tumor microenvironment (TME) and highly heterogeneous nature, making it resistant to radiotherapy. This study aims to evaluate the radiosensitizing effect of homocamptothecin derivative TOP-0618 o...

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Bibliographic Details
Main Authors: Yin Tang, Chengyi Huang, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Liang You, Zhenyuan Miao, Huojun Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
Radiosensitivity
TOP-0618
Homocamptothecin derivative
Online Access:https://doi.org/10.1186/s12885-025-14347-x
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