Mendelian randomization analysis of the causal association between metabolite and skin cancer
Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore th...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-03-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/dr/article/view/10159 |
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| author | Duanyu Wang Minghao Tan Nora Iv Rattanaricky Ung Gechhorng Lim Vahid Say Sokheng Phal Pengkhun Nov |
| author_facet | Duanyu Wang Minghao Tan Nora Iv Rattanaricky Ung Gechhorng Lim Vahid Say Sokheng Phal Pengkhun Nov |
| author_sort | Duanyu Wang |
| collection | DOAJ |
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Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore the causal association between metabolites and SC risks using a Mendelian randomization (MR) approach. Our analysis revealed a total of 76 metabolites associated with SC risk. Of them, leucine to N-palmitoyl-sphingosine ratio, glycerol to palmitoylcarnitine ratio, oleoyl-linoleoyl-glycerol levels, and hypotaurine-to-taurine ratio were strongly associated with SC. Notably, leucine to N-palmitoyl-sphingosine ratio and glycerol to palmitoylcarnitine ratio were linked to increased risk factors for SC. However, oleoyl-linoleoyl-glycerol levels and hypotaurine-to-taurine ratio served as the protective indicators of SC. This study highlights the potential role of metabolites in skin cancer etiology, suggesting that metabolic factors may serve as important targets for prevention and risk assessment strategies.
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| format | Article |
| id | doaj-art-1246f906b63045d0be5ce453ecc5498a |
| institution | DOAJ |
| issn | 2036-7392 2036-7406 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj-art-1246f906b63045d0be5ce453ecc5498a2025-08-20T02:57:17ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062025-03-0110.4081/dr.2025.10159Mendelian randomization analysis of the causal association between metabolite and skin cancerDuanyu Wang0Minghao Tan1Nora Iv2Rattanaricky Ung3Gechhorng Lim4Vahid Say5Sokheng Phal6Pengkhun Nov7Department of Oncology, Xiangya Hospital of Central South University, Changsha, Hunan ProvinceDepartment of Gastrointestinal Surgery, Liuzhou Workers Hospital, Liuzhou, Guangxi ProvinceOncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong ProvinceOncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong ProvinceOncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong ProvinceOncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong ProvinceOncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong ProvinceOncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore the causal association between metabolites and SC risks using a Mendelian randomization (MR) approach. Our analysis revealed a total of 76 metabolites associated with SC risk. Of them, leucine to N-palmitoyl-sphingosine ratio, glycerol to palmitoylcarnitine ratio, oleoyl-linoleoyl-glycerol levels, and hypotaurine-to-taurine ratio were strongly associated with SC. Notably, leucine to N-palmitoyl-sphingosine ratio and glycerol to palmitoylcarnitine ratio were linked to increased risk factors for SC. However, oleoyl-linoleoyl-glycerol levels and hypotaurine-to-taurine ratio served as the protective indicators of SC. This study highlights the potential role of metabolites in skin cancer etiology, suggesting that metabolic factors may serve as important targets for prevention and risk assessment strategies. https://www.pagepress.org/journals/dr/article/view/10159Skin cancermetabolitesMendelian randomizationcausal associationepidemiology |
| spellingShingle | Duanyu Wang Minghao Tan Nora Iv Rattanaricky Ung Gechhorng Lim Vahid Say Sokheng Phal Pengkhun Nov Mendelian randomization analysis of the causal association between metabolite and skin cancer Dermatology Reports Skin cancer metabolites Mendelian randomization causal association epidemiology |
| title | Mendelian randomization analysis of the causal association between metabolite and skin cancer |
| title_full | Mendelian randomization analysis of the causal association between metabolite and skin cancer |
| title_fullStr | Mendelian randomization analysis of the causal association between metabolite and skin cancer |
| title_full_unstemmed | Mendelian randomization analysis of the causal association between metabolite and skin cancer |
| title_short | Mendelian randomization analysis of the causal association between metabolite and skin cancer |
| title_sort | mendelian randomization analysis of the causal association between metabolite and skin cancer |
| topic | Skin cancer metabolites Mendelian randomization causal association epidemiology |
| url | https://www.pagepress.org/journals/dr/article/view/10159 |
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