Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism
Aim. To assess the neurological status and index of neuropsychological development in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism. Materials and methods. To study the FADS2 rs174583 (C/T) gene polymorphism, 170 children were examined. The children were...
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Zaporizhzhia State Medical and Pharmaceutical University
2020-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/214737/214892 |
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| author | T. Yе. Shumna T. O. Levchuk-Vorontsova |
| author_facet | T. Yе. Shumna T. O. Levchuk-Vorontsova |
| author_sort | T. Yе. Shumna |
| collection | DOAJ |
| description | Aim. To assess the neurological status and index of neuropsychological development in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism.
Materials and methods. To study the FADS2 rs174583 (C/T) gene polymorphism, 170 children were examined. The children were divided into 3 groups depending on their birth weight: group I included 53 children (birth weight was 1500–1999 g, gestation period – 33.0 [32.0; 35.0] weeks), group II included 77 children (birth weight – 2000–2499 g, gestation period – 35.0 [34.0; 36.0] weeks), group III was composed of 40 children as a control (birth weight – more than 2500 g, gestation period – 38.0 [36.0; 39.0] weeks). The genotyping was carried out using a polymerase chain reaction method.
Results. The C allele and the С/Т genotype frequencies of the FADS2 rs174583 gene polymorphism in the children matched those in North-Western Europe. Seizures in the past medical history due to the nervous system disorders were most commonly occurred in children with the TT genotype (16.45 %, P < 0.05), while patients with the CC genotype had seizures in only 5.6 % of cases. Children with a birth weight of 1500–1999 g carrying the C/T heterozygous genotype and the T/T homozygous genotype of the FADS2 (rs1745683) gene polymorphism had a lower total Apgar score than children with a birth weight of more than 2000 g (P < 0.05). The coefficient of psychomotor development was the lowest in children with birth weight of 1500-1999 g and the minor homozygous T/T genotype of the FADS2 (rs1745683) gene polymorphism, at 83.0 (75.0; 83.0), which corresponded to a weak normal level of the neuropsychiatric development, while the highest index of psychomotor development (116.0 (112.0; 141.0)) and a normal high level of neuropsychiatric development were significantly registered in children with birth weight of 2500 g and the major homozygous C/C genotype.
Conclusions. It is possible that the predominance of the homozygous C/C genotype and the heterozygous C/T genotype fulfils a protective function in order to reduce the negative effects of preterm birth on the nervous system |
| format | Article |
| id | doaj-art-1246abc73ee845fcb7fd550ebbfd5263 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
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| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-1246abc73ee845fcb7fd550ebbfd52632025-08-20T02:02:10ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102020-10-0122565266310.14739/2310-1210.2020.5.214737Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphismT. Yе. Shumna 0T. O. Levchuk-Vorontsova1 Zaporizhzhia State Medical University, Ukraine Zaporizhzhia State Medical University, UkraineAim. To assess the neurological status and index of neuropsychological development in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism. Materials and methods. To study the FADS2 rs174583 (C/T) gene polymorphism, 170 children were examined. The children were divided into 3 groups depending on their birth weight: group I included 53 children (birth weight was 1500–1999 g, gestation period – 33.0 [32.0; 35.0] weeks), group II included 77 children (birth weight – 2000–2499 g, gestation period – 35.0 [34.0; 36.0] weeks), group III was composed of 40 children as a control (birth weight – more than 2500 g, gestation period – 38.0 [36.0; 39.0] weeks). The genotyping was carried out using a polymerase chain reaction method. Results. The C allele and the С/Т genotype frequencies of the FADS2 rs174583 gene polymorphism in the children matched those in North-Western Europe. Seizures in the past medical history due to the nervous system disorders were most commonly occurred in children with the TT genotype (16.45 %, P < 0.05), while patients with the CC genotype had seizures in only 5.6 % of cases. Children with a birth weight of 1500–1999 g carrying the C/T heterozygous genotype and the T/T homozygous genotype of the FADS2 (rs1745683) gene polymorphism had a lower total Apgar score than children with a birth weight of more than 2000 g (P < 0.05). The coefficient of psychomotor development was the lowest in children with birth weight of 1500-1999 g and the minor homozygous T/T genotype of the FADS2 (rs1745683) gene polymorphism, at 83.0 (75.0; 83.0), which corresponded to a weak normal level of the neuropsychiatric development, while the highest index of psychomotor development (116.0 (112.0; 141.0)) and a normal high level of neuropsychiatric development were significantly registered in children with birth weight of 2500 g and the major homozygous C/C genotype. Conclusions. It is possible that the predominance of the homozygous C/C genotype and the heterozygous C/T genotype fulfils a protective function in order to reduce the negative effects of preterm birth on the nervous systemhttp://zmj.zsmu.edu.ua/article/view/214737/214892allelesgenotypespolyunsaturated fatty acidspreterm birthchildren |
| spellingShingle | T. Yе. Shumna T. O. Levchuk-Vorontsova Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism Zaporožskij Medicinskij Žurnal alleles genotypes polyunsaturated fatty acids preterm birth children |
| title | Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism |
| title_full | Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism |
| title_fullStr | Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism |
| title_full_unstemmed | Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism |
| title_short | Assessment of the nervous system state in low birth weight children taking into account the FADS2 rs174583 (C/T) gene polymorphism |
| title_sort | assessment of the nervous system state in low birth weight children taking into account the fads2 rs174583 c t gene polymorphism |
| topic | alleles genotypes polyunsaturated fatty acids preterm birth children |
| url | http://zmj.zsmu.edu.ua/article/view/214737/214892 |
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