Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling

Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling

Abstract EGFR‐mutated lung cancer patients sometimes display restricted responses to third‐generation tyrosine kinase inhibitors (TKIs), potentially attributable to undervalued input from stromal cells, notably pericytes (PCs). The study shows that PCs isolated from EGFR‐mutated patients have a uniq...

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Bibliographic Details
Main Authors: Cheng Huang, Xi Huang, Xiaoyi Qiu, Xiangzhan Kong, Chunmiao Wu, Xue Jiang, Mingkang Yao, Minghui Wang, Liangping Su, Cui Lv, Ping‐Pui Wong
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
β5‐integrin
non‐small cell lung cancer
pericytes
tyrosine kinase inhibitor sensitivity
Online Access:https://doi.org/10.1002/advs.202405130
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