Preclinical pharmacokinetics, distribution, metabolism and excretion of disitamab vedotin
Background and purpose: Disitamab vedotin is an antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody (mAb) targeting HER2 conjugated to monomethyl auristatin E(MMAE) via a cleavable dipeptide linker. Experimental approach: The pharmacokinetics, distribution, catabolism/met...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2025-03-01
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| Series: | ADMET and DMPK |
| Subjects: | |
| Online Access: | https://pub.iapchem.org/ojs/index.php/admet/article/view/2582 |
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