Preclinical pharmacokinetics, distribution, metabolism and excretion of disitamab vedotin

Preclinical pharmacokinetics, distribution, metabolism and excretion of disitamab vedotin

Background and purpose: Disitamab vedotin is an antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody (mAb) targeting HER2 conjugated to monomethyl auristatin E(MMAE) via a cleavable dipeptide linker. Experimental approach: The pharmacokinetics, distribution, catabolism/met...

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Bibliographic Details
Main Authors: Ling Wang, Limeng Zhu, Fengzhu Wang, Lihou Dong, Zhihao Liu, Fang Chen, Jing Jiang
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2025-03-01
Series:ADMET and DMPK
Subjects:
Antibody-drug conjugate
physiological disposition
monomethyl auristatin E (MMAE)
mass balance
Online Access:https://pub.iapchem.org/ojs/index.php/admet/article/view/2582
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