Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice.

Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice.

Interleukin-1 (IL-1) is a key pro-inflammatory cytokine, produced predominantly by peripheral immune cells but also by glia and some neuronal populations within the brain. Its signalling is mediated via the binding of IL-1α or IL-1β to the interleukin-1 type one receptor (IL-1RI). IL-1 plays a key r...

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Bibliographic Details
Main Authors: Carol L Murray, Pauline Obiang, David Bannerman, Colm Cunningham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0078385
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