Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice

Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice

Abstract Chronic kidney disease is a life‐threatening disease worldwide. PPARα is a crucial transcriptional regulator of lipid metabolism and inflammation. Here, we examine whether a novel selective PPARα modulator, pemafibrate modulates renal injury in a model of unilateral ureteral obstruction (UU...

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Main Authors: Kunihiko Takahara, Noriyuki Ouchi, Tomonobu Takikawa, Yuta Ozaki, Lixin Fang, Hiroshi Kawanishi, Minako Tatsumi, Yoshimitsu Yura, Katsuhiro Kato, Mikito Takefuji, Toyoaki Murohara, Koji Ohashi
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Physiological Reports
Subjects:
FGF21
inflammation
pemafibrate
PPARα
β‐hydroxybutyrate
Online Access:https://doi.org/10.14814/phy2.70135
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