Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula
Background: To investigate the visual acuity outcome and choroid thickness (CT) change after intravitreal ranibizumab in highly myopic eyes with or without dome-shaped macula (DSM) in Chinese patients. Methods: This retrospective, observative study included 80 treatment-naive eyes (80 patients), whi...
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Elsevier
2024-12-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024003867 |
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| author | Xiao-Fang Yin Zu-Ke Ye Xiu-Juan Guo Chen Liang Min-Hui Wu Yu-Ting Luo Yan Lu |
| author_facet | Xiao-Fang Yin Zu-Ke Ye Xiu-Juan Guo Chen Liang Min-Hui Wu Yu-Ting Luo Yan Lu |
| author_sort | Xiao-Fang Yin |
| collection | DOAJ |
| description | Background: To investigate the visual acuity outcome and choroid thickness (CT) change after intravitreal ranibizumab in highly myopic eyes with or without dome-shaped macula (DSM) in Chinese patients. Methods: This retrospective, observative study included 80 treatment-naive eyes (80 patients), which received ranibizumab according to the 1+PRN protocol. The best corrective visual acuity (BCVA) and CT change were compared between eyes with or without DSM. Results: There was no significant difference between eyes with or without DSM in BCVA and central macular thickness (CMT). The recurrent rate was not different between the two groups during the first year of treatment. The CT was significantly thinner in eyes with DSM than in eyes without DSM before treatment (median 40.00um versus 71.00um), at 1 month after treatment (median 31.00um versus 65.50um), and in the last follow up (median, 32.00um versus 65.00um) (p = 0.0101). Axial length (AL) was longer in eyes with DSM than those without DSM (median, 29.17 mm versus 28.10 mm) before treatment, and in the last follow up (median, 29.44 mm versus 28.20 mm) (p = 0.0055). The CT was significantly correlated with AL (p < 0.0001). Conclusions: No difference was found in visual outcome between eyes with or without DSM. The visual acuity significantly improved at 1 month after ranibizumab injection and it was recovery sooner in extrafoveal choroidal neovascularization (CNV) group than in subfoveal CNV group. The CT was thinner in eyes with DSM, which was significantly correlated with AL. |
| format | Article |
| id | doaj-art-122c8e700f3846f1b2e78bd0ef54164b |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-122c8e700f3846f1b2e78bd0ef54164b2025-08-20T01:59:34ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-12-015010434910.1016/j.pdpdt.2024.104349Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped maculaXiao-Fang Yin0Zu-Ke Ye1Xiu-Juan Guo2Chen Liang3Min-Hui Wu4Yu-Ting Luo5Yan Lu6Department of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaDepartment of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaCorresponding author.; Department of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaDepartment of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaDepartment of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaDepartment of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaDepartment of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, ChinaBackground: To investigate the visual acuity outcome and choroid thickness (CT) change after intravitreal ranibizumab in highly myopic eyes with or without dome-shaped macula (DSM) in Chinese patients. Methods: This retrospective, observative study included 80 treatment-naive eyes (80 patients), which received ranibizumab according to the 1+PRN protocol. The best corrective visual acuity (BCVA) and CT change were compared between eyes with or without DSM. Results: There was no significant difference between eyes with or without DSM in BCVA and central macular thickness (CMT). The recurrent rate was not different between the two groups during the first year of treatment. The CT was significantly thinner in eyes with DSM than in eyes without DSM before treatment (median 40.00um versus 71.00um), at 1 month after treatment (median 31.00um versus 65.50um), and in the last follow up (median, 32.00um versus 65.00um) (p = 0.0101). Axial length (AL) was longer in eyes with DSM than those without DSM (median, 29.17 mm versus 28.10 mm) before treatment, and in the last follow up (median, 29.44 mm versus 28.20 mm) (p = 0.0055). The CT was significantly correlated with AL (p < 0.0001). Conclusions: No difference was found in visual outcome between eyes with or without DSM. The visual acuity significantly improved at 1 month after ranibizumab injection and it was recovery sooner in extrafoveal choroidal neovascularization (CNV) group than in subfoveal CNV group. The CT was thinner in eyes with DSM, which was significantly correlated with AL.http://www.sciencedirect.com/science/article/pii/S1572100024003867Myopic choroidal neovascularizationDome-shaped maculaRanibizumabChoroidal thicknessOptical coherence tomography |
| spellingShingle | Xiao-Fang Yin Zu-Ke Ye Xiu-Juan Guo Chen Liang Min-Hui Wu Yu-Ting Luo Yan Lu Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula Photodiagnosis and Photodynamic Therapy Myopic choroidal neovascularization Dome-shaped macula Ranibizumab Choroidal thickness Optical coherence tomography |
| title | Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula |
| title_full | Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula |
| title_fullStr | Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula |
| title_full_unstemmed | Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula |
| title_short | Comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome-shaped macula |
| title_sort | comparison of visual acuity outcome and choroidal thickness variation of intravitreal ranibizumab injection for myopic choroidal neovascularization with or without dome shaped macula |
| topic | Myopic choroidal neovascularization Dome-shaped macula Ranibizumab Choroidal thickness Optical coherence tomography |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024003867 |
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