The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases
The medical records of 186 patients diagnosed with Guillain-Barré syndrome (GBS) who had been followed up at the Research Center of Neurology, Russian Academy of Medical Sciences, in 2000 to 2011 were retrospectively analyzed. Most (65 %) of the patients had severe GBS; 19 % of the patients were on...
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2015-02-01
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| Series: | Нервно-мышечные болезни |
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| author | N. A. Suponeva E. G. Mochalova D. A. Grishina M. A. Piradov |
| author_facet | N. A. Suponeva E. G. Mochalova D. A. Grishina M. A. Piradov |
| author_sort | N. A. Suponeva |
| collection | DOAJ |
| description | The medical records of 186 patients diagnosed with Guillain-Barré syndrome (GBS) who had been followed up at the Research Center of Neurology, Russian Academy of Medical Sciences, in 2000 to 2011 were retrospectively analyzed. Most (65 %) of the patients had severe GBS; 19 % of the patients were on mechanical ventilation (MV) for an average of 21 (13; 48) days. The forms of GBS, such as acute inflammatory demyelinating polyneuropathy (AIDP) (n = 141; 78 %), and axonal variants, such as acute motor axonal neuropathy (AMAN), acute sensorimotor axonal neuropathy (AMSAN), i. e. AMAN / AMSAN (n = 39; 22 %), were studied separately. There was a significant difference in the seasonal revalence (p < 0.05). AIDP was encountered evenly throughout the year; AMAN / AMSAN occurred in 46 % of cases in summer. AIDP was followed by acute respiratory viral infection in 35 % of cases; diarrhea wasby the axonal forms in 36 % (p < 0.05). The axonal forms ran a severer course than AIDP: MV was performed twice more frequently (33 and 15 %, respectively); its duration was 6‑fold longer: 90 (46; 102) and 15 (10; 21) days (p < 0.05). AMAN / AMSAN was characterized by a severer neurological status and disability in the acute period, as shown by the NIS, MRCss, INCAT, R-ODS, and Barthel scales; these patients showed a poorer response to pathogenetic therapy (p < 0.05): 59 % with an insufficient effect; 15 % of those with AIDP. After six years, the majority (84 %) of the patients with AIDP walked alone and only 16 % were assisted. In the same period, less than half of the patients (40 %) with AMAN / AMSAN walked alone and a third (29 %) could move with assistance and almost the same percentage (31 %) could not walk.Thus, a number of specific features of GBS were found in a Russian population (equal age and sex distribution; a larger percentage of the axonal forms than in European countries and the United States); however, the most characteristics did not differ from the global data. |
| format | Article |
| id | doaj-art-12275143a1444f40b35e580609f8f4e6 |
| institution | Kabale University |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2015-02-01 |
| publisher | ABV-press |
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| series | Нервно-мышечные болезни |
| spelling | doaj-art-12275143a1444f40b35e580609f8f4e62025-08-20T04:00:20ZrusABV-pressНервно-мышечные болезни2222-87212413-04432015-02-0101374610.17650/2222-8721-2014-0-1-40-474The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 casesN. A. Suponeva0E. G. Mochalova1D. A. Grishina2M. A. Piradov3Research Center of Neurology, Russian Academy of Medical Sciences, MoscowMoscow State University named after M.V. LomonosovResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowThe medical records of 186 patients diagnosed with Guillain-Barré syndrome (GBS) who had been followed up at the Research Center of Neurology, Russian Academy of Medical Sciences, in 2000 to 2011 were retrospectively analyzed. Most (65 %) of the patients had severe GBS; 19 % of the patients were on mechanical ventilation (MV) for an average of 21 (13; 48) days. The forms of GBS, such as acute inflammatory demyelinating polyneuropathy (AIDP) (n = 141; 78 %), and axonal variants, such as acute motor axonal neuropathy (AMAN), acute sensorimotor axonal neuropathy (AMSAN), i. e. AMAN / AMSAN (n = 39; 22 %), were studied separately. There was a significant difference in the seasonal revalence (p < 0.05). AIDP was encountered evenly throughout the year; AMAN / AMSAN occurred in 46 % of cases in summer. AIDP was followed by acute respiratory viral infection in 35 % of cases; diarrhea wasby the axonal forms in 36 % (p < 0.05). The axonal forms ran a severer course than AIDP: MV was performed twice more frequently (33 and 15 %, respectively); its duration was 6‑fold longer: 90 (46; 102) and 15 (10; 21) days (p < 0.05). AMAN / AMSAN was characterized by a severer neurological status and disability in the acute period, as shown by the NIS, MRCss, INCAT, R-ODS, and Barthel scales; these patients showed a poorer response to pathogenetic therapy (p < 0.05): 59 % with an insufficient effect; 15 % of those with AIDP. After six years, the majority (84 %) of the patients with AIDP walked alone and only 16 % were assisted. In the same period, less than half of the patients (40 %) with AMAN / AMSAN walked alone and a third (29 %) could move with assistance and almost the same percentage (31 %) could not walk.Thus, a number of specific features of GBS were found in a Russian population (equal age and sex distribution; a larger percentage of the axonal forms than in European countries and the United States); however, the most characteristics did not differ from the global data.https://nmb.abvpress.ru/jour/article/view/10guillain–barré syndromeacute inflammatory demyelinating polyneuropathyacute motor axonal neuropathyacute sensorimotor axonal neuropathyaxonal neuropathytriggerprecipitating factorseveritytherapeutic effectivenessrecovery |
| spellingShingle | N. A. Suponeva E. G. Mochalova D. A. Grishina M. A. Piradov The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases Нервно-мышечные болезни guillain–barré syndrome acute inflammatory demyelinating polyneuropathy acute motor axonal neuropathy acute sensorimotor axonal neuropathy axonal neuropathy trigger precipitating factor severity therapeutic effectiveness recovery |
| title | The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases |
| title_full | The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases |
| title_fullStr | The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases |
| title_full_unstemmed | The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases |
| title_short | The specific features of Guillain–Barré syndrome in Russia: Analysis of 186 cases |
| title_sort | specific features of guillain barre syndrome in russia analysis of 186 cases |
| topic | guillain–barré syndrome acute inflammatory demyelinating polyneuropathy acute motor axonal neuropathy acute sensorimotor axonal neuropathy axonal neuropathy trigger precipitating factor severity therapeutic effectiveness recovery |
| url | https://nmb.abvpress.ru/jour/article/view/10 |
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