Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer
This case report highlights the management of a delayed bronchopleural fistula (BPF) following salvage pulmonary resection to achieve local control and no radiographic evidence of disease in a patient treated with serial tyrosine kinase inhibitors (TKIs) for stage IV anaplastic lymphoma kinase (ALK)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/5/250 |
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| author | Lauren Barter Stephanie Snow Aneil Mujoomdar Lara Best Daniel French |
| author_facet | Lauren Barter Stephanie Snow Aneil Mujoomdar Lara Best Daniel French |
| author_sort | Lauren Barter |
| collection | DOAJ |
| description | This case report highlights the management of a delayed bronchopleural fistula (BPF) following salvage pulmonary resection to achieve local control and no radiographic evidence of disease in a patient treated with serial tyrosine kinase inhibitors (TKIs) for stage IV anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). The initial pulmonary resection was complicated by dense adhesions and an abnormally torturous pulmonary artery. Six weeks after the index surgery, the patient presented with a delayed BPF requiring decortication, repair of airway, and coverage of the bronchial stump with a serratus anterior muscle flap. |
| format | Article |
| id | doaj-art-121ec36abc984ebab4a54d88f7c6a3f0 |
| institution | DOAJ |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-121ec36abc984ebab4a54d88f7c6a3f02025-08-20T03:14:39ZengMDPI AGCurrent Oncology1198-00521718-77292025-04-0132525010.3390/curroncol32050250Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung CancerLauren Barter0Stephanie Snow1Aneil Mujoomdar2Lara Best3Daniel French4Faculty of Medicine, Carleton Campus, Dalhousie University, 5849 University Ave., Halifax, NS B3H 4R2, CanadaFaculty of Medicine, Carleton Campus, Dalhousie University, 5849 University Ave., Halifax, NS B3H 4R2, CanadaFaculty of Medicine, Carleton Campus, Dalhousie University, 5849 University Ave., Halifax, NS B3H 4R2, CanadaFaculty of Medicine, Carleton Campus, Dalhousie University, 5849 University Ave., Halifax, NS B3H 4R2, CanadaFaculty of Medicine, Carleton Campus, Dalhousie University, 5849 University Ave., Halifax, NS B3H 4R2, CanadaThis case report highlights the management of a delayed bronchopleural fistula (BPF) following salvage pulmonary resection to achieve local control and no radiographic evidence of disease in a patient treated with serial tyrosine kinase inhibitors (TKIs) for stage IV anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). The initial pulmonary resection was complicated by dense adhesions and an abnormally torturous pulmonary artery. Six weeks after the index surgery, the patient presented with a delayed BPF requiring decortication, repair of airway, and coverage of the bronchial stump with a serratus anterior muscle flap.https://www.mdpi.com/1718-7729/32/5/250lung cancerALK targeted therapysalvage surgerybronchopleural fistulaserratus muscle flap |
| spellingShingle | Lauren Barter Stephanie Snow Aneil Mujoomdar Lara Best Daniel French Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer Current Oncology lung cancer ALK targeted therapy salvage surgery bronchopleural fistula serratus muscle flap |
| title | Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer |
| title_full | Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer |
| title_fullStr | Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer |
| title_full_unstemmed | Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer |
| title_short | Delayed Bronchopleural Fistula Formation Following Salvage Surgery of Stage IV Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer |
| title_sort | delayed bronchopleural fistula formation following salvage surgery of stage iv anaplastic lymphoma kinase positive non small cell lung cancer |
| topic | lung cancer ALK targeted therapy salvage surgery bronchopleural fistula serratus muscle flap |
| url | https://www.mdpi.com/1718-7729/32/5/250 |
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