Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

IntroductionThe retinoblastoma protein (pRb) is a key regulator of the cell cycle that suppresses cell proliferation by binding to E2F transcription factors. Disruption of this pathway, commonly through mutations or interactions with viral oncoproteins, can lead to uncontrolled cell growth and cance...

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Bibliographic Details
Main Authors: Carla Luciana Padilla Franzotti, Nicolas Palopoli, Juliana Palma, Gustavo Pierdominici-Sottile
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Chemical Biology
Subjects:
pRb
E2F
LTSV40
retinoblastoma protein
viral oncoproteins
MD simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fchbi.2025.1538350/full
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