Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study
Abstract Objective Prevalence, susceptibility genes, and clinical and radiological features may differ across different ethnic groups of multiple sclerosis (MS). We aim to characterize brain lesions in Chinese patients with MS by use of 7‐T MRI. Methods MS participants were enrolled from the ongoing...
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Wiley
2025-02-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.52256 |
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| author | Lei Su Zhe Zhang Chenyang Gao Ai Guo Mengting Zhang Xiaoyu Shi Xinyao Liu Tian Song Wangshu Xu Huabing Wang Joseph Kuchling Jing Jing De‐Cai Tian Yaou Liu Yunyun Duan Friedemann Paul Fu‐Dong Shi |
| author_facet | Lei Su Zhe Zhang Chenyang Gao Ai Guo Mengting Zhang Xiaoyu Shi Xinyao Liu Tian Song Wangshu Xu Huabing Wang Joseph Kuchling Jing Jing De‐Cai Tian Yaou Liu Yunyun Duan Friedemann Paul Fu‐Dong Shi |
| author_sort | Lei Su |
| collection | DOAJ |
| description | Abstract Objective Prevalence, susceptibility genes, and clinical and radiological features may differ across different ethnic groups of multiple sclerosis (MS). We aim to characterize brain lesions in Chinese patients with MS by use of 7‐T MRI. Methods MS participants were enrolled from the ongoing China National Registry of Neuro‐Inflammatory Diseases (CNRID) cohort. 7‐T MRI of the brain was performed. Each lesion was evaluated according to a standardized procedure. Central vein sign (CVS) and paramagnetic rim lesions were identified. The characteristics of lesions at patient‐level and at lesion‐level from previous 7‐T MRI literature were also summarized. Results We included 120 MS patients. Their mean (SD) age was 34.6 (9.4) years. The female‐to‐male ratio was 1.7:1 and mean disease duration of patients with MS was 5.5 ± 6.1 years. The median EDSS score was 2 (range, 0–8). A total of 8502 lesions were identified with a median lesion count of 45 (IQR, 18–90) (range, 2–370). The median (IQR) percentage for these special locations were as follows: cortical lesions (CLs) 2.7% (0%–5.7%), juxtacortical lesions 16.2% (7.8%–25.7%), periventricular lesions 30.2% (17.2%–38.7%), and infratentorial lesions 5.8% (0.4%–11.9%). CLs occurred in 70 (58%) patients, accounting for only 443 (5%) of the total lesions. Out of the 443 CLs, 309 (69.8%) were leukocortical lesions. CVS appeared in 5392 (63%) lesions from 117 (98%) patients. 1792 (21%) lesions and 104 (87%) patients exhibited a paramagnetic rim. Interpretation Our study elaborated on the lesion features of Chinese patients with MS by use of 7‐T MRI. Lesion burden is heavy in Chinese patients with MS. The median lesion count and proportion of PRL are high. The reported heavy lesion burden calls for ramping up regional and global efforts to care for MS patients. The management and research of Chinese population with MS needs to be further strengthened. |
| format | Article |
| id | doaj-art-1218c6068d064fd6ab12df2f2eacdf78 |
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| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-1218c6068d064fd6ab12df2f2eacdf782025-08-20T02:28:00ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-02-0112230031010.1002/acn3.52256Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort studyLei Su0Zhe Zhang1Chenyang Gao2Ai Guo3Mengting Zhang4Xiaoyu Shi5Xinyao Liu6Tian Song7Wangshu Xu8Huabing Wang9Joseph Kuchling10Jing Jing11De‐Cai Tian12Yaou Liu13Yunyun Duan14Friedemann Paul15Fu‐Dong Shi16Departments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité‐Universitätsmedizin Berlin Humboldt Universität zu Berlin, Berlin Institute of Health Berlin GermanyDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité‐Universitätsmedizin Berlin Humboldt Universität zu Berlin, Berlin Institute of Health Berlin GermanyDepartments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaAbstract Objective Prevalence, susceptibility genes, and clinical and radiological features may differ across different ethnic groups of multiple sclerosis (MS). We aim to characterize brain lesions in Chinese patients with MS by use of 7‐T MRI. Methods MS participants were enrolled from the ongoing China National Registry of Neuro‐Inflammatory Diseases (CNRID) cohort. 7‐T MRI of the brain was performed. Each lesion was evaluated according to a standardized procedure. Central vein sign (CVS) and paramagnetic rim lesions were identified. The characteristics of lesions at patient‐level and at lesion‐level from previous 7‐T MRI literature were also summarized. Results We included 120 MS patients. Their mean (SD) age was 34.6 (9.4) years. The female‐to‐male ratio was 1.7:1 and mean disease duration of patients with MS was 5.5 ± 6.1 years. The median EDSS score was 2 (range, 0–8). A total of 8502 lesions were identified with a median lesion count of 45 (IQR, 18–90) (range, 2–370). The median (IQR) percentage for these special locations were as follows: cortical lesions (CLs) 2.7% (0%–5.7%), juxtacortical lesions 16.2% (7.8%–25.7%), periventricular lesions 30.2% (17.2%–38.7%), and infratentorial lesions 5.8% (0.4%–11.9%). CLs occurred in 70 (58%) patients, accounting for only 443 (5%) of the total lesions. Out of the 443 CLs, 309 (69.8%) were leukocortical lesions. CVS appeared in 5392 (63%) lesions from 117 (98%) patients. 1792 (21%) lesions and 104 (87%) patients exhibited a paramagnetic rim. Interpretation Our study elaborated on the lesion features of Chinese patients with MS by use of 7‐T MRI. Lesion burden is heavy in Chinese patients with MS. The median lesion count and proportion of PRL are high. The reported heavy lesion burden calls for ramping up regional and global efforts to care for MS patients. The management and research of Chinese population with MS needs to be further strengthened.https://doi.org/10.1002/acn3.52256 |
| spellingShingle | Lei Su Zhe Zhang Chenyang Gao Ai Guo Mengting Zhang Xiaoyu Shi Xinyao Liu Tian Song Wangshu Xu Huabing Wang Joseph Kuchling Jing Jing De‐Cai Tian Yaou Liu Yunyun Duan Friedemann Paul Fu‐Dong Shi Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study Annals of Clinical and Translational Neurology |
| title | Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study |
| title_full | Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study |
| title_fullStr | Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study |
| title_full_unstemmed | Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study |
| title_short | Brain lesion characteristics in Chinese multiple sclerosis patients: A 7‐T MRI cohort study |
| title_sort | brain lesion characteristics in chinese multiple sclerosis patients a 7 t mri cohort study |
| url | https://doi.org/10.1002/acn3.52256 |
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