Placental and immune cell DNA methylation reference panel for bulk tissue cell composition estimation in epidemiological studies

Placental and immune cell DNA methylation reference panel for bulk tissue cell composition estimation in epidemiological studies

To distinguish DNA methylation (DNAm) from cell proportion changes in whole placental villous tissue research, we developed a robust cell type-specific DNAm reference to estimate cell composition. We collated new and existing cell type DNAm profiles quantified via Illumina EPIC or 450k microarrays....

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Bibliographic Details
Main Authors: Kyle A. Campbell, Justin A. Colacino, John Dou, Dana C. Dolinoy, Sung Kyun Park, Rita Loch-Caruso, Vasantha Padmanabhan, Kelly M. Bakulski
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Epigenetics
Subjects:
DNA methylation
placenta
blood cells
deconvolution
epigenetics
Online Access:https://www.tandfonline.com/doi/10.1080/15592294.2024.2437275
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