Recent Advances in Chemical Modification of Peptide Nucleic Acids
Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental s...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.1155/2012/518162 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560714378641408 |
|---|---|
| author | Eriks Rozners |
| author_facet | Eriks Rozners |
| author_sort | Eriks Rozners |
| collection | DOAJ |
| description | Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental science and practical applications. The present paper discusses selected recent studies that improve on cellular uptake and binding of PNA to double-stranded DNA and RNA. The focus is on chemical modifications of PNA's backbone and heterocyclic nucleobases. The paper selects representative recent studies and does not attempt to provide comprehensive coverage of the broad and vibrant field of PNA modification. |
| format | Article |
| id | doaj-art-12071b8a84f6463d95594104ac1e59ae |
| institution | Kabale University |
| issn | 2090-0201 2090-021X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-12071b8a84f6463d95594104ac1e59ae2025-02-03T01:26:53ZengWileyJournal of Nucleic Acids2090-02012090-021X2012-01-01201210.1155/2012/518162518162Recent Advances in Chemical Modification of Peptide Nucleic AcidsEriks Rozners0Department of Chemistry, Binghamton University, State University of New York, 4400 Vestal Parkway East, Binghamton, NY 13902, USAPeptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental science and practical applications. The present paper discusses selected recent studies that improve on cellular uptake and binding of PNA to double-stranded DNA and RNA. The focus is on chemical modifications of PNA's backbone and heterocyclic nucleobases. The paper selects representative recent studies and does not attempt to provide comprehensive coverage of the broad and vibrant field of PNA modification.http://dx.doi.org/10.1155/2012/518162 |
| spellingShingle | Eriks Rozners Recent Advances in Chemical Modification of Peptide Nucleic Acids Journal of Nucleic Acids |
| title | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
| title_full | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
| title_fullStr | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
| title_full_unstemmed | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
| title_short | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
| title_sort | recent advances in chemical modification of peptide nucleic acids |
| url | http://dx.doi.org/10.1155/2012/518162 |
| work_keys_str_mv | AT eriksrozners recentadvancesinchemicalmodificationofpeptidenucleicacids |