Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions
This study has evaluated whether systemic changes of plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) parallel the adhesions development and whether they could be used as predictors of adhesion risk. This has been studied in an animal model of post-surgical peritoneal adh...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/13901 |
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| author | Clara Di Filippo Alessandro Falsetto Vito De Pascale Elisabetta Tufariello Domenico De Lucia Francesco Rossi Michele D'Amico Antonio Cennamo |
| author_facet | Clara Di Filippo Alessandro Falsetto Vito De Pascale Elisabetta Tufariello Domenico De Lucia Francesco Rossi Michele D'Amico Antonio Cennamo |
| author_sort | Clara Di Filippo |
| collection | DOAJ |
| description | This study has evaluated whether systemic changes of plasminogen
activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1)
parallel the adhesions development and whether they could be used
as predictors of adhesion risk. This has been studied in an animal
model of post-surgical peritoneal adhesion by monitoring for 10
days the plasma and tissue levels of t-PA and PAI-1. The results
showed that both tissular and plasmatic levels of t-PA
were decreased in concomitance with the development of peritoneal
adhesions. In contrast, PAI-1 was found increased into the tissue
and into the plasma samples of the rats taken at 5 and 10 days
time points. Inflammatory mediators such as ICAM-1, VCAM-1, and
IL-6 within the peritoneal lavage fluid also correlated with the
adhesion formation process. In conclusion, post-surgical
peritoneal adhesions provide alterations of local inflammatory
components and local and systemic fibrinolytic components,
possibly with PAI-1 quenching t-PA. This may have potential for
the identification of high-risk patients. |
| format | Article |
| id | doaj-art-1206de40b2f14643a6cc76914072c45a |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1206de40b2f14643a6cc76914072c45a2025-08-20T02:01:54ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/1390113901Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal AdhesionsClara Di Filippo0Alessandro Falsetto1Vito De Pascale2Elisabetta Tufariello3Domenico De Lucia4Francesco Rossi5Michele D'Amico6Antonio Cennamo7Section of Pharmacology L. Donatelli, Department of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Anaesthetic Sciences and Emergency Surgery, Second University of Naples, Naples 80138, ItalyDepartment of Anaesthetic Sciences and Emergency Surgery, Second University of Naples, Naples 80138, ItalySection of Pharmacology L. Donatelli, Department of Experimental Medicine, Second University of Naples, Naples 80138, ItalyLaboratory of Hemostasis and Thrombosis, Second University of Naples, Naples 80138, ItalySection of Pharmacology L. Donatelli, Department of Experimental Medicine, Second University of Naples, Naples 80138, ItalySection of Pharmacology L. Donatelli, Department of Experimental Medicine, Second University of Naples, Naples 80138, ItalyDepartment of Anaesthetic Sciences and Emergency Surgery, Second University of Naples, Naples 80138, ItalyThis study has evaluated whether systemic changes of plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) parallel the adhesions development and whether they could be used as predictors of adhesion risk. This has been studied in an animal model of post-surgical peritoneal adhesion by monitoring for 10 days the plasma and tissue levels of t-PA and PAI-1. The results showed that both tissular and plasmatic levels of t-PA were decreased in concomitance with the development of peritoneal adhesions. In contrast, PAI-1 was found increased into the tissue and into the plasma samples of the rats taken at 5 and 10 days time points. Inflammatory mediators such as ICAM-1, VCAM-1, and IL-6 within the peritoneal lavage fluid also correlated with the adhesion formation process. In conclusion, post-surgical peritoneal adhesions provide alterations of local inflammatory components and local and systemic fibrinolytic components, possibly with PAI-1 quenching t-PA. This may have potential for the identification of high-risk patients.http://dx.doi.org/10.1155/MI/2006/13901 |
| spellingShingle | Clara Di Filippo Alessandro Falsetto Vito De Pascale Elisabetta Tufariello Domenico De Lucia Francesco Rossi Michele D'Amico Antonio Cennamo Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions Mediators of Inflammation |
| title | Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions |
| title_full | Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions |
| title_fullStr | Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions |
| title_full_unstemmed | Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions |
| title_short | Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions |
| title_sort | plasma levels of t pa and pai 1 correlate with the formation of experimental post surgical peritoneal adhesions |
| url | http://dx.doi.org/10.1155/MI/2006/13901 |
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