Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions
This study has evaluated whether systemic changes of plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) parallel the adhesions development and whether they could be used as predictors of adhesion risk. This has been studied in an animal model of post-surgical peritoneal adh...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/13901 |
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| Summary: | This study has evaluated whether systemic changes of plasminogen
activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1)
parallel the adhesions development and whether they could be used
as predictors of adhesion risk. This has been studied in an animal
model of post-surgical peritoneal adhesion by monitoring for 10
days the plasma and tissue levels of t-PA and PAI-1. The results
showed that both tissular and plasmatic levels of t-PA
were decreased in concomitance with the development of peritoneal
adhesions. In contrast, PAI-1 was found increased into the tissue
and into the plasma samples of the rats taken at 5 and 10 days
time points. Inflammatory mediators such as ICAM-1, VCAM-1, and
IL-6 within the peritoneal lavage fluid also correlated with the
adhesion formation process. In conclusion, post-surgical
peritoneal adhesions provide alterations of local inflammatory
components and local and systemic fibrinolytic components,
possibly with PAI-1 quenching t-PA. This may have potential for
the identification of high-risk patients. |
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| ISSN: | 0962-9351 1466-1861 |