Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study
Abstract Objectives Endoscopic submucosal resection with band ligation (ESMR‐L) and endoscopic submucosal dissection (ESD) are both standard endoscopic resection methods for rectal neuroendocrine tumors (NETs) <10 mm in size. However, there is no definitive consensus on which is better. Here, we...
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2023-04-01
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| Online Access: | https://doi.org/10.1002/deo2.163 |
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| author | Kenshi Matsuno Hideaki Miyamoto Hideki Kitada Shinichi Yoshimatsu Fumio Tamura Kouichi Sakurai Kotaro Fukubayashi Takashi Shono Hiroko Setoyama Taichi Matsuyama Shinichiro Suko Rei Narita Munenori Honda Masakuni Tateyama Hideaki Naoe Jun Morinaga Yasuhito Tanaka Ryosuke Gushima |
| author_facet | Kenshi Matsuno Hideaki Miyamoto Hideki Kitada Shinichi Yoshimatsu Fumio Tamura Kouichi Sakurai Kotaro Fukubayashi Takashi Shono Hiroko Setoyama Taichi Matsuyama Shinichiro Suko Rei Narita Munenori Honda Masakuni Tateyama Hideaki Naoe Jun Morinaga Yasuhito Tanaka Ryosuke Gushima |
| author_sort | Kenshi Matsuno |
| collection | DOAJ |
| description | Abstract Objectives Endoscopic submucosal resection with band ligation (ESMR‐L) and endoscopic submucosal dissection (ESD) are both standard endoscopic resection methods for rectal neuroendocrine tumors (NETs) <10 mm in size. However, there is no definitive consensus on which is better. Here, we compared the efficacy of ESMR‐L and ESD for small rectal NETs. Methods This was a multicenter retrospective cohort study including 205 patients with rectal NETs who underwent ESMR‐L or ESD. Treatment outcomes were compared by univariate analysis, multivariate analysis, and inverse probability treatment weighting (IPTW) using propensity scores. Subgroup analysis evaluated the impact of the endoscopist's experience on the technical outcome. Results Eighty‐nine patients were treated by ESMR‐L and 116 by ESD. The R0 resection rate was not significantly different between the two (90% vs. 92%, p = 0.73). The procedure time of ESMR‐L was significantly shorter than for ESD (17 min vs. 52 min, p < 0.01) and the hospitalization period was also significantly shorter (3 days vs. 5 days, p < 0.01). These results were confirmed by multivariate analysis and also after IPTW adjustment. The procedure time of ESD was significantly prolonged by a less‐experienced endoscopist (49 min vs. 70 min, p = 0.02), but that of ESMR‐L was not affected (17 min vs. 17 min, p = 0.27). Conclusions For small rectal NETs, both ESMR‐L and ESD showed similar high complete resection rates. However, considering the shorter procedure time and shorter hospitalization period, ESMR‐L is the more efficient treatment method, especially for less‐experienced endoscopists. |
| format | Article |
| id | doaj-art-11ff21f9f0f84bca8537b81da6250e2b |
| institution | OA Journals |
| issn | 2692-4609 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-11ff21f9f0f84bca8537b81da6250e2b2025-08-20T01:50:18ZengWileyDEN Open2692-46092023-04-0131n/an/a10.1002/deo2.163Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective studyKenshi Matsuno0Hideaki Miyamoto1Hideki Kitada2Shinichi Yoshimatsu3Fumio Tamura4Kouichi Sakurai5Kotaro Fukubayashi6Takashi Shono7Hiroko Setoyama8Taichi Matsuyama9Shinichiro Suko10Rei Narita11Munenori Honda12Masakuni Tateyama13Hideaki Naoe14Jun Morinaga15Yasuhito Tanaka16Ryosuke Gushima17Department of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterology Japanese Red Cross Kumamoto Hospital Kumamoto JapanDepartment of Gastroenterology Kumamoto General Hospital Community Health Care Organization Kumamoto JapanDepartment of Gastroenterology Kumamoto Regional Medical Center Kumamoto JapanHattori Clinic Kumamoto JapanDepartment of Gastroenterology Tamana Central Hospital Kumamoto JapanDepartment of Gastroenterology Kumamoto Chuo Hospital Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterology National Hospital Organization Kumamoto Medical Center Kumamoto JapanDepartment of Gastroenterology Saiseikai Kumamoto Hospital Kumamoto JapanDepartment of Gastroenterology Minamata City Hospital and Medical Center Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Clinical Investigation (Biostatistics) Kumamoto University Hospital Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University Kumamoto JapanAbstract Objectives Endoscopic submucosal resection with band ligation (ESMR‐L) and endoscopic submucosal dissection (ESD) are both standard endoscopic resection methods for rectal neuroendocrine tumors (NETs) <10 mm in size. However, there is no definitive consensus on which is better. Here, we compared the efficacy of ESMR‐L and ESD for small rectal NETs. Methods This was a multicenter retrospective cohort study including 205 patients with rectal NETs who underwent ESMR‐L or ESD. Treatment outcomes were compared by univariate analysis, multivariate analysis, and inverse probability treatment weighting (IPTW) using propensity scores. Subgroup analysis evaluated the impact of the endoscopist's experience on the technical outcome. Results Eighty‐nine patients were treated by ESMR‐L and 116 by ESD. The R0 resection rate was not significantly different between the two (90% vs. 92%, p = 0.73). The procedure time of ESMR‐L was significantly shorter than for ESD (17 min vs. 52 min, p < 0.01) and the hospitalization period was also significantly shorter (3 days vs. 5 days, p < 0.01). These results were confirmed by multivariate analysis and also after IPTW adjustment. The procedure time of ESD was significantly prolonged by a less‐experienced endoscopist (49 min vs. 70 min, p = 0.02), but that of ESMR‐L was not affected (17 min vs. 17 min, p = 0.27). Conclusions For small rectal NETs, both ESMR‐L and ESD showed similar high complete resection rates. However, considering the shorter procedure time and shorter hospitalization period, ESMR‐L is the more efficient treatment method, especially for less‐experienced endoscopists.https://doi.org/10.1002/deo2.163colonoscopyendoscopic resectionendoscopic submucosal dissectionendoscopic submucosal resection with band ligationrectal neuroendocrine tumors |
| spellingShingle | Kenshi Matsuno Hideaki Miyamoto Hideki Kitada Shinichi Yoshimatsu Fumio Tamura Kouichi Sakurai Kotaro Fukubayashi Takashi Shono Hiroko Setoyama Taichi Matsuyama Shinichiro Suko Rei Narita Munenori Honda Masakuni Tateyama Hideaki Naoe Jun Morinaga Yasuhito Tanaka Ryosuke Gushima Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study DEN Open colonoscopy endoscopic resection endoscopic submucosal dissection endoscopic submucosal resection with band ligation rectal neuroendocrine tumors |
| title | Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study |
| title_full | Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study |
| title_fullStr | Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study |
| title_full_unstemmed | Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study |
| title_short | Comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors: A multicenter retrospective study |
| title_sort | comparison of endoscopic submucosal resection with ligation and endoscopic submucosal dissection for small rectal neuroendocrine tumors a multicenter retrospective study |
| topic | colonoscopy endoscopic resection endoscopic submucosal dissection endoscopic submucosal resection with band ligation rectal neuroendocrine tumors |
| url | https://doi.org/10.1002/deo2.163 |
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