Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease
Neuroinflammation and cytokine-dependent neurotoxicity appear to be major contributors to the neuropathology in Parkinson’s disease (PD). While pharmacological advancements have been a mainstay in the treatment of PD for decades, it is becoming increasingly clear that nonpharmacological approaches i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8814028 |
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| _version_ | 1849309411186573312 |
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| author | Gabriella Policastro Matteo Brunelli Michele Tinazzi Cristiano Chiamulera Dwaine F. Emerich Giovanna Paolone |
| author_facet | Gabriella Policastro Matteo Brunelli Michele Tinazzi Cristiano Chiamulera Dwaine F. Emerich Giovanna Paolone |
| author_sort | Gabriella Policastro |
| collection | DOAJ |
| description | Neuroinflammation and cytokine-dependent neurotoxicity appear to be major contributors to the neuropathology in Parkinson’s disease (PD). While pharmacological advancements have been a mainstay in the treatment of PD for decades, it is becoming increasingly clear that nonpharmacological approaches including traditional and nontraditional forms of exercise and physical rehabilitation can be critical adjunctive or even primary treatment avenues. Here, we provide an overview of preclinical and clinical research detailing the biological role of proinflammatory molecules in PD and how motor rehabilitation can be used to therapeutically modulate neuroinflammation, restore neural plasticity, and improve motor function in PD. |
| format | Article |
| id | doaj-art-11fa41b2bb1246d6956dfcd5e304ecdc |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-11fa41b2bb1246d6956dfcd5e304ecdc2025-08-20T03:54:11ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88140288814028Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s DiseaseGabriella Policastro0Matteo Brunelli1Michele Tinazzi2Cristiano Chiamulera3Dwaine F. Emerich4Giovanna Paolone5Department of Diagnostic and Public Health, University of Verona, Verona, ItalyDepartment of Diagnostic and Public Health, University of Verona, Verona, ItalyDepartment of Neuroscience, Biomedicine and Movement, University of Verona, Verona, ItalyDepartment of Diagnostic and Public Health, University of Verona, Verona, ItalyGlocester, Rhode Island, USADepartment of Diagnostic and Public Health, University of Verona, Verona, ItalyNeuroinflammation and cytokine-dependent neurotoxicity appear to be major contributors to the neuropathology in Parkinson’s disease (PD). While pharmacological advancements have been a mainstay in the treatment of PD for decades, it is becoming increasingly clear that nonpharmacological approaches including traditional and nontraditional forms of exercise and physical rehabilitation can be critical adjunctive or even primary treatment avenues. Here, we provide an overview of preclinical and clinical research detailing the biological role of proinflammatory molecules in PD and how motor rehabilitation can be used to therapeutically modulate neuroinflammation, restore neural plasticity, and improve motor function in PD.http://dx.doi.org/10.1155/2020/8814028 |
| spellingShingle | Gabriella Policastro Matteo Brunelli Michele Tinazzi Cristiano Chiamulera Dwaine F. Emerich Giovanna Paolone Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease Neural Plasticity |
| title | Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease |
| title_full | Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease |
| title_fullStr | Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease |
| title_full_unstemmed | Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease |
| title_short | Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease |
| title_sort | cytokine neurotrophin and motor rehabilitation induced plasticity in parkinson s disease |
| url | http://dx.doi.org/10.1155/2020/8814028 |
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