Determining the functional relationship between epigenetic and physical chromatin domains in Drosophila

Determining the functional relationship between epigenetic and physical chromatin domains in Drosophila

Abstract The tight correlation between topologically associating domains (TADs) and epigenetic domains in Drosophila suggests that the epigenome contributes to define TADs. However, it is still unknown whether histone modifications are essential for TAD formation and structure. By either deleting or...

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Bibliographic Details
Main Authors: Sandrine Denaud, Gonzalo Sabarís, Marco Di Stefano, Giorgio-Lucio Papadopoulos, Bernd Schuettengruber, Giacomo Cavalli
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Biology
Subjects:
Chromatin
Genome organization
Epigenome
TADs
Drosophila
PcG proteins
Online Access:https://doi.org/10.1186/s13059-025-03587-6
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