In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis
Background: Dysregulated myocardial calcium handling has been demonstrated in ischemic, non-ischemic and diabetic cardiomyopathy. Manganese-enhanced MRI (MEMRI) provides a unique method to quantify in-vivo myocardial calcium uptake but no studies have so far utilized MEMRI in patients with aortic st...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724011013 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850119309836156928 |
|---|---|
| author | Abhishek Dattani Saadia Aslam Gaurav S. Gulsin Aseel Alfuhied Trisha Singh Shruti S. Joshi Lucy E. Kershaw David E. Newby Gerry P. McCann Anvesha Singh |
| author_facet | Abhishek Dattani Saadia Aslam Gaurav S. Gulsin Aseel Alfuhied Trisha Singh Shruti S. Joshi Lucy E. Kershaw David E. Newby Gerry P. McCann Anvesha Singh |
| author_sort | Abhishek Dattani |
| collection | DOAJ |
| description | Background: Dysregulated myocardial calcium handling has been demonstrated in ischemic, non-ischemic and diabetic cardiomyopathy. Manganese-enhanced MRI (MEMRI) provides a unique method to quantify in-vivo myocardial calcium uptake but no studies have so far utilized MEMRI in patients with aortic stenosis (AS). We sought to: 1) determine whether myocardial calcium uptake is perturbed in people with severe AS, and 2) assess change in calcium uptake following aortic valve replacement (AVR). Methods: In this prospective, pilot, case-control study, adults with severe AS underwent MEMRI before and after AVR. A group of healthy controls were also recruited. The primary outcome was the rate of manganese uptake (Ki) as assessed by Patlak modeling to act as a surrogate of myocardial calcium uptake. Comparison of Ki between groups was adjusted for age, body mass index (BMI) and systolic blood pressure. Results: Twenty-eight controls and ten subjects with severe AS (age 72 [61-75] years, 8 male, 7 symptomatic, valve area 0.81 [0.74-1.0] cm2) were recruited, with seven returning for repeat scans post-AVR. AS patients had higher BMI and blood pressure, and a greater incidence of hyperlipidemia compared to controls. Baseline left ventricular (LV) volumes were similar between the groups, but the AS patients had higher indexed left ventricular mass. Global longitudinal strain and peak early diastolic strain rate were lower in the AS group. There was no significant difference in Ki between patients with severe AS and controls (7.09 [6.33-8.99] vs. 8.15 [7.54-8.78] mL/100g of tissue/min, P=0.815). Following AVR, there was regression in indexed LV mass (68 [51-79] to 49 [47-65] g/m2, P=0.018) and mass-volume ratio (0.94 [0.80-1.13] to 0.74 [0.71-0.82] g/mL, P=0.028) but no change in Ki was seen (7.35 [6.81-8.96] to 7.11 [6.16-8.01] mL/100 g of tissue/min, P=0.499). Conclusions: Despite clear features of adverse LV remodeling and systolic dysfunction, patients with severe AS demonstrated no alteration in calcium uptake at baseline compared to controls. Moreover, AVR led to reverse LV remodeling but no notable change in calcium uptake was seen. This may suggest that altered myocardial calcium handling does not play a significant pathophysiological role in AS. |
| format | Article |
| id | doaj-art-11f43cb0aed2418aa9545b01f4e3dc4e |
| institution | OA Journals |
| issn | 1097-6647 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-11f43cb0aed2418aa9545b01f4e3dc4e2025-08-20T02:35:40ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472024-01-0126210107410.1016/j.jocmr.2024.101074In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosisAbhishek Dattani0Saadia Aslam1Gaurav S. Gulsin2Aseel Alfuhied3Trisha Singh4Shruti S. Joshi5Lucy E. Kershaw6David E. Newby7Gerry P. McCann8Anvesha Singh9Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK; College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UKCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UKCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UKCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UKDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK; Correspondence to: Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKBackground: Dysregulated myocardial calcium handling has been demonstrated in ischemic, non-ischemic and diabetic cardiomyopathy. Manganese-enhanced MRI (MEMRI) provides a unique method to quantify in-vivo myocardial calcium uptake but no studies have so far utilized MEMRI in patients with aortic stenosis (AS). We sought to: 1) determine whether myocardial calcium uptake is perturbed in people with severe AS, and 2) assess change in calcium uptake following aortic valve replacement (AVR). Methods: In this prospective, pilot, case-control study, adults with severe AS underwent MEMRI before and after AVR. A group of healthy controls were also recruited. The primary outcome was the rate of manganese uptake (Ki) as assessed by Patlak modeling to act as a surrogate of myocardial calcium uptake. Comparison of Ki between groups was adjusted for age, body mass index (BMI) and systolic blood pressure. Results: Twenty-eight controls and ten subjects with severe AS (age 72 [61-75] years, 8 male, 7 symptomatic, valve area 0.81 [0.74-1.0] cm2) were recruited, with seven returning for repeat scans post-AVR. AS patients had higher BMI and blood pressure, and a greater incidence of hyperlipidemia compared to controls. Baseline left ventricular (LV) volumes were similar between the groups, but the AS patients had higher indexed left ventricular mass. Global longitudinal strain and peak early diastolic strain rate were lower in the AS group. There was no significant difference in Ki between patients with severe AS and controls (7.09 [6.33-8.99] vs. 8.15 [7.54-8.78] mL/100g of tissue/min, P=0.815). Following AVR, there was regression in indexed LV mass (68 [51-79] to 49 [47-65] g/m2, P=0.018) and mass-volume ratio (0.94 [0.80-1.13] to 0.74 [0.71-0.82] g/mL, P=0.028) but no change in Ki was seen (7.35 [6.81-8.96] to 7.11 [6.16-8.01] mL/100 g of tissue/min, P=0.499). Conclusions: Despite clear features of adverse LV remodeling and systolic dysfunction, patients with severe AS demonstrated no alteration in calcium uptake at baseline compared to controls. Moreover, AVR led to reverse LV remodeling but no notable change in calcium uptake was seen. This may suggest that altered myocardial calcium handling does not play a significant pathophysiological role in AS.http://www.sciencedirect.com/science/article/pii/S1097664724011013Aortic stenosisCalciumManganese-enhanced MRI |
| spellingShingle | Abhishek Dattani Saadia Aslam Gaurav S. Gulsin Aseel Alfuhied Trisha Singh Shruti S. Joshi Lucy E. Kershaw David E. Newby Gerry P. McCann Anvesha Singh In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis Journal of Cardiovascular Magnetic Resonance Aortic stenosis Calcium Manganese-enhanced MRI |
| title | In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis |
| title_full | In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis |
| title_fullStr | In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis |
| title_full_unstemmed | In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis |
| title_short | In-vivo assessment of myocardial calcium uptake using manganese-enhanced cardiovascular magnetic resonance in aortic stenosis |
| title_sort | in vivo assessment of myocardial calcium uptake using manganese enhanced cardiovascular magnetic resonance in aortic stenosis |
| topic | Aortic stenosis Calcium Manganese-enhanced MRI |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724011013 |
| work_keys_str_mv | AT abhishekdattani invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT saadiaaslam invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT gauravsgulsin invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT aseelalfuhied invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT trishasingh invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT shrutisjoshi invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT lucyekershaw invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT davidenewby invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT gerrypmccann invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis AT anveshasingh invivoassessmentofmyocardialcalciumuptakeusingmanganeseenhancedcardiovascularmagneticresonanceinaorticstenosis |